Synthesis and biological evaluation of chalcones having heterosubstituent(s)

Sweety, S. Kumar, K. Nepali, S. Sapra, O. P. Suri, K. L. Dhar, G. S. Sarma, A. K. Saxena

研究成果: 雜誌貢獻文章

9 引文 斯高帕斯(Scopus)

摘要

Chalcones and their synthetic analogues appear to have the same binding site of tubuline as phenstatin, combretastatin steganacin and podophylotoxin and are therefore capable to inhibit cancer cell proliferation. The phenyl rings with appropriate substitutions maintain a fixed distance between two centers of aryl rings. The two aromatic rings in these molecules are arranged like the two wings of a butterfly having certain dihedral angle between them, therefore a "butterfly model" is proposed an important structural feature responsible for their antitubulin activity. In this sequence a series of chalcones were synthesized and evaluated for in vitro cytotoxic activity against a panel of human cancer cell lines. In addition the synthetics reduced MIC of ciprofloxacin upto four fold this indicates their bioavailability enhancing potential.
原文英語
頁(從 - 到)801-806
頁數6
期刊Indian Journal of Pharmaceutical Sciences
72
發行號6
DOIs
出版狀態已發佈 - 十一月 1 2010

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Sweety, Kumar, S., Nepali, K., Sapra, S., Suri, O. P., Dhar, K. L., Sarma, G. S., & Saxena, A. K. (2010). Synthesis and biological evaluation of chalcones having heterosubstituent(s). Indian Journal of Pharmaceutical Sciences, 72(6), 801-806. https://doi.org/10.4103/0250-474X.84602