Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh, Hsueh Yun Lee, Chih Ying Nien, Ching Chuan Kuo, Chi Yen Chang, Jang Yang Chang, Jing Ping Liou

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

原文英語
頁(從 - 到)2274-2284
頁數11
期刊Molecules
16
發行號3
DOIs
出版狀態已發佈 - 三月 2011

指紋

cultured cells
Antineoplastic Agents
cancer
Cells
Cell Line
evaluation
synthesis
Inhibitory Concentration 50
Neoplasms
analogs
Growth
combretastatin

ASJC Scopus subject areas

  • Organic Chemistry

引用此文

Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents. / Hsieh, Cheng Chih; Lee, Hsueh Yun; Nien, Chih Ying; Kuo, Ching Chuan; Chang, Chi Yen; Chang, Jang Yang; Liou, Jing Ping.

於: Molecules, 卷 16, 編號 3, 03.2011, p. 2274-2284.

研究成果: 雜誌貢獻文章

Hsieh, Cheng Chih ; Lee, Hsueh Yun ; Nien, Chih Ying ; Kuo, Ching Chuan ; Chang, Chi Yen ; Chang, Jang Yang ; Liou, Jing Ping. / Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents. 於: Molecules. 2011 ; 卷 16, 編號 3. 頁 2274-2284.
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AU - Nien, Chih Ying

AU - Kuo, Ching Chuan

AU - Chang, Chi Yen

AU - Chang, Jang Yang

AU - Liou, Jing Ping

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