Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents

Cheng Chih Hsieh, Hsueh Yun Lee, Chih Ying Nien, Ching Chuan Kuo, Chi Yen Chang, Jang Yang Chang, Jing Ping Liou

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)

摘要

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC50 values of 217, 327, 239, 246, 213, and 252 nM, respectively.

原文英語
頁(從 - 到)2274-2284
頁數11
期刊Molecules
16
發行號3
DOIs
出版狀態已發佈 - 三月 2011

ASJC Scopus subject areas

  • Organic Chemistry

指紋 深入研究「Synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents」主題。共同形成了獨特的指紋。

  • 引用此