SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES

JAMES BLAKE, WEN‐CHANG ‐C CHANG, CHOH HAO LI

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.
原文英語
頁(從 - 到)275-280
頁數6
期刊International Journal of Peptide and Protein Research
14
發行號3
DOIs
出版狀態已發佈 - 一月 1 1979
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Biochemistry

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