Three analogs of human β‐endorphin containing internal cystine bridges have been synthesized and their biological activities have been determined. It was found that the analogs with disulfide bridges between positions 17 and 26 or 11 and 26 retained full opiate activity as estimated by guinea ileum assay, whereas the analog with a cystine bridge between positions 7 and 26 showed reduced opiate activity. None of the analogs retained significant immunoactivity as revealed by radioimmunoassay.
|頁（從 - 到）||275-280|
|期刊||International Journal of Peptide and Protein Research|
|出版狀態||已發佈 - 一月 1 1979|
ASJC Scopus subject areas
BLAKE, JAMES., CHANG, WENCHANG. C., & LI, CHOH. HAO. (1979). SYNTHESIS AND BIOLOGICAL ACTIVITY OF HUMAN β‐ENDORPHIN ANALOGS WITH DISULFIDE BRIDGES. International Journal of Peptide and Protein Research, 14(3), 275-280. https://doi.org/10.1111/j.1399-3011.1979.tb01933.x