Synthesis and antitumor activity of 1,8-diaminoanthraquinone derivatives

Hsu Shan Huang, Hui F. Chiu, Wei Chih Lu, Chun Lung Yuan

研究成果: 雜誌貢獻文章

22 引文 斯高帕斯(Scopus)

摘要

Continuing our ongoing studies on cytotoxic substances, a series of regioisomeric disubstituted aminoanthraquinone (DAAQ) derivatives have been synthesized as cytotoxic activity based on a proposed bioactive amino conformation. To assess the biological activity of amino-substitution in the side-chains of anthraquinone located at positions 1 and 8 of the anthraquinone ring system. The aim of the study was to determine if members of the anthraquinone family could be used as adjuncts to increase the growth inhibiting effect of anticancer agents in rat glioma C6 cells, human hepatoma G2 cells and 2.2.15 cells. In vitro cytotoxicity data is reported for the compounds and some indications of structure-activity relationships have been discerned. A number of compounds were found to have good cytotoxicity against proliferation in these three cell lines. This has led to the discovery some of the DAAQ as a conformationally constrained structure possessing anticancer properties that displays cytotoxicity for these above cell lines and is being investigated further.
原文英語
頁(從 - 到)1136-1139
頁數4
期刊Chemical and Pharmaceutical Bulletin
53
發行號9
DOIs
出版狀態已發佈 - 九月 2005
對外發佈Yes

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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