Synthesis and anti-inflammation evaluation of new C60 fulleropyrrolidines bearing biologically active xanthine

Sheng Tung Huang, Jian Sheng Liao, Hsu Wei Fang, Chun Mao Lin

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

摘要

We designed and prepared the new C60 fullerene hybrids bearing a xanthine moiety as potential double-action anti-inflammatory agents, capable of simultaneous inhibition of LPS-induced NO and TNF-α production. The 10 μM of fulleropyrrolidine-xanthine dyad 2a and b were effective in suppressing LPS-induced NO production by 55.1 ± 2.1% and 58.6 ± 2.6%, respectively, but only 2b was also effectively in suppressing LPS-induced TNF-α production by 34.0 ± 2.7%. We believed that the agents synthesized herein would hold promise for future development of a new generation of potent anti-inflammatory agents.
原文英語
頁(從 - 到)99-103
頁數5
期刊Bioorganic and Medicinal Chemistry Letters
18
發行號1
DOIs
出版狀態已發佈 - 一月 1 2008

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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