Synergistic antibacterial effects of localized heat and oxidative stress caused by hydroxyl radicals mediated by graphene/iron oxide-based nanocomposites

Wen Yu Pan, Chieh Cheng Huang, Tzu Tsen Lin, Hsin Yi Hu, Wei Chih Lin, Meng Ju Li, Hsing Wen Sung

研究成果: 雜誌貢獻文章同行評審

73 引文 斯高帕斯(Scopus)

摘要

This work develops a composite system of reduced graphene oxide (rGO)-iron oxide nanoparticles (rGO-IONP) that can synergistically induce physical and chemical damage to methicillin-resistant Staphylococcus aureus (MRSA) that are present in subcutaneous abscesses. rGO-IONP was synthesized by the chemical deposition of Fe2+/Fe3+ ions on nanosheets of rGO in aqueous ammonia. The antibacterial efficacy of the as-prepared rGO-IONP was evaluated in a mouse model with MRSA-infected subcutaneous abscesses. Upon exposure to a near-infrared laser in vitro, rGO-IONP synergistically generated localized heat and large amounts of hydroxyl radicals, which inactivated MRSA. The in vivo results reveal that combined treatment with localized heat and oxidative stress that is caused by hydroxyl radicals accelerated the healing of wounds associated with MRSA-infected abscesses. The above results demonstrate that an rGO-IONP nanocomposite system that can effectively inactivate multiple-drug-resistant bacteria in subcutaneous infections was successfully developed. From the Clinical Editor: The emergence of methicillin-resistant S. aureus (MRSA) has posed a significant problem in the clinical setting. Thus, it is imperative to develop new treatment strategies against this. In this study, the authors described the use of reduced graphene oxide (rGO)-iron oxide nanoparticles (rGO-IONP) to induce heat and chemical damage to MRSA. This approach may provide a platform the design of other treatment modalities against multiple-drug-resistant bacteria.
原文英語
頁(從 - 到)431-438
頁數8
期刊Nanomedicine: Nanotechnology, Biology, and Medicine
12
發行號2
DOIs
出版狀態已發佈 - 2月 1 2016

ASJC Scopus subject areas

  • 生物工程
  • 醫藥(雜項)
  • 分子醫學
  • 生物醫學工程
  • 材料科學(全部)
  • 藥學科學

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