Sustained-release of oxytetracycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods

Mi Fwu-Long, Tsung Bi Wong, Shin Shing Shyu

研究成果: 雜誌貢獻文章同行評審

29 引文 斯高帕斯(Scopus)

摘要

Chitosan microspheres containing oxytetracycline (OTC), an antibiotic agent, were prepared by spray hardening and interfacial acylation methods. The object of this study was to prepare oxytetracycline-containing microspheres for oral administration and injection using different molecular weight (Mw 70,000 ~ 2,000,000) of chitosan. By the spray hardening method, microspheres with particle sizes between 5 and 30 μm could be obtained and might be suitable for intramuscular injection. On the other hand, chitosan microspheres with the ability to extend the dissolution period of oxytetracycline in low pH medium were also prepared by the interfacial acylation method. The result indicated that the releasing of oxytetracycline from various acylated chitosan microspheres was decreased with increasing the molecular weight of chitosan and would show well sustained-release property. Besides, the morphology of various microspheres and crystalline form transition of oxytetracycline were also studied using electron scanning microscope and X-ray analysis.

原文英語
頁(從 - 到)577-591
頁數15
期刊Journal of Microencapsulation
14
發行號5
DOIs
出版狀態已發佈 - 1997
對外發佈Yes

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry

指紋 深入研究「Sustained-release of oxytetracycline from chitosan microspheres prepared by interfacial acylation and spray hardening methods」主題。共同形成了獨特的指紋。

引用此