Susceptibility-weighted MRI in mild traumatic brain injury

研究成果: 雜誌貢獻文章

39 引文 (Scopus)

摘要

Objective: To compare the frequency of microbleeds identified by susceptibility-weighted MRI (SWMRI) in patients with mild traumatic brain injury (mTBI) and normal controls, and correlate these findings with neuropsychological tests. Methods: Research ethics committee approval and patient written informed consents were obtained. One hundred eleven patients with mTBI without parenchymal hemorrhage on CT and conventional MRI received SWMRI as well as a digit span and continuous performance test. One hundred eleven healthy volunteers without history of traumatic brain injury were enrolled as the control group and received conventional MRI with additional SWMRI study. We analyzed the number and location of microbleeds in both groups. Results: Twenty-six patients with mTBI and 12 control subjects presented microbleeds on SWMRI (p 0.0197). Sixty microbleeds were found in 26 patients with mTBI and 15 microbleeds in 12 control subjects. The mTBI group showed notably more microbleeds in the cortex/subcortical region (52 microbleeds, 86.7%, vs 3 microbleeds, 20%; p < 0.0001). Conversely, the control group showed more microbleeds in the central brain (9 microbleeds, 60%, vs 3 microbleeds, 5%; p < 0.0001). There was no statistical difference in number of microbleeds in the cerebellum and brainstem (p 0.2598 and p 0.4932, respectively). Patients with mTBI who had detected microbleeds had lower digit span scores than the patients with negative SWMRI findings (p 0.017). Conclusion: Presence of mTBI-related microbleeds showed a neuropsychological defect on short-term memory function, indicating that the presence of microbleeds could be a possible severity biomarker for mTBI. Addition of the SWMRI technique to the MRI protocol for patients with mTBI is recommended.
原文英語
頁(從 - 到)580-585
頁數6
期刊Neurology
84
發行號6
DOIs
出版狀態已發佈 - 二月 10 2015

指紋

Brain Concussion
Control Groups
Neuropsychological Tests
Research Ethics Committees
Informed Consent
Short-Term Memory
Cerebellum
Brain Stem
Healthy Volunteers
Biomarkers
Hemorrhage

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

引用此文

Susceptibility-weighted MRI in mild traumatic brain injury. / Huang, Yen Lin; Kuo, Ying Sheng; Tseng, Ying-Chi; Chen, David Yen Ting; Chiu, Wen-Ta; Chen, Chi-Jen.

於: Neurology, 卷 84, 編號 6, 10.02.2015, p. 580-585.

研究成果: 雜誌貢獻文章

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title = "Susceptibility-weighted MRI in mild traumatic brain injury",
abstract = "Objective: To compare the frequency of microbleeds identified by susceptibility-weighted MRI (SWMRI) in patients with mild traumatic brain injury (mTBI) and normal controls, and correlate these findings with neuropsychological tests. Methods: Research ethics committee approval and patient written informed consents were obtained. One hundred eleven patients with mTBI without parenchymal hemorrhage on CT and conventional MRI received SWMRI as well as a digit span and continuous performance test. One hundred eleven healthy volunteers without history of traumatic brain injury were enrolled as the control group and received conventional MRI with additional SWMRI study. We analyzed the number and location of microbleeds in both groups. Results: Twenty-six patients with mTBI and 12 control subjects presented microbleeds on SWMRI (p 0.0197). Sixty microbleeds were found in 26 patients with mTBI and 15 microbleeds in 12 control subjects. The mTBI group showed notably more microbleeds in the cortex/subcortical region (52 microbleeds, 86.7{\%}, vs 3 microbleeds, 20{\%}; p <0.0001). Conversely, the control group showed more microbleeds in the central brain (9 microbleeds, 60{\%}, vs 3 microbleeds, 5{\%}; p <0.0001). There was no statistical difference in number of microbleeds in the cerebellum and brainstem (p 0.2598 and p 0.4932, respectively). Patients with mTBI who had detected microbleeds had lower digit span scores than the patients with negative SWMRI findings (p 0.017). Conclusion: Presence of mTBI-related microbleeds showed a neuropsychological defect on short-term memory function, indicating that the presence of microbleeds could be a possible severity biomarker for mTBI. Addition of the SWMRI technique to the MRI protocol for patients with mTBI is recommended.",
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AU - Huang, Yen Lin

AU - Kuo, Ying Sheng

AU - Tseng, Ying-Chi

AU - Chen, David Yen Ting

AU - Chiu, Wen-Ta

AU - Chen, Chi-Jen

PY - 2015/2/10

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N2 - Objective: To compare the frequency of microbleeds identified by susceptibility-weighted MRI (SWMRI) in patients with mild traumatic brain injury (mTBI) and normal controls, and correlate these findings with neuropsychological tests. Methods: Research ethics committee approval and patient written informed consents were obtained. One hundred eleven patients with mTBI without parenchymal hemorrhage on CT and conventional MRI received SWMRI as well as a digit span and continuous performance test. One hundred eleven healthy volunteers without history of traumatic brain injury were enrolled as the control group and received conventional MRI with additional SWMRI study. We analyzed the number and location of microbleeds in both groups. Results: Twenty-six patients with mTBI and 12 control subjects presented microbleeds on SWMRI (p 0.0197). Sixty microbleeds were found in 26 patients with mTBI and 15 microbleeds in 12 control subjects. The mTBI group showed notably more microbleeds in the cortex/subcortical region (52 microbleeds, 86.7%, vs 3 microbleeds, 20%; p <0.0001). Conversely, the control group showed more microbleeds in the central brain (9 microbleeds, 60%, vs 3 microbleeds, 5%; p <0.0001). There was no statistical difference in number of microbleeds in the cerebellum and brainstem (p 0.2598 and p 0.4932, respectively). Patients with mTBI who had detected microbleeds had lower digit span scores than the patients with negative SWMRI findings (p 0.017). Conclusion: Presence of mTBI-related microbleeds showed a neuropsychological defect on short-term memory function, indicating that the presence of microbleeds could be a possible severity biomarker for mTBI. Addition of the SWMRI technique to the MRI protocol for patients with mTBI is recommended.

AB - Objective: To compare the frequency of microbleeds identified by susceptibility-weighted MRI (SWMRI) in patients with mild traumatic brain injury (mTBI) and normal controls, and correlate these findings with neuropsychological tests. Methods: Research ethics committee approval and patient written informed consents were obtained. One hundred eleven patients with mTBI without parenchymal hemorrhage on CT and conventional MRI received SWMRI as well as a digit span and continuous performance test. One hundred eleven healthy volunteers without history of traumatic brain injury were enrolled as the control group and received conventional MRI with additional SWMRI study. We analyzed the number and location of microbleeds in both groups. Results: Twenty-six patients with mTBI and 12 control subjects presented microbleeds on SWMRI (p 0.0197). Sixty microbleeds were found in 26 patients with mTBI and 15 microbleeds in 12 control subjects. The mTBI group showed notably more microbleeds in the cortex/subcortical region (52 microbleeds, 86.7%, vs 3 microbleeds, 20%; p <0.0001). Conversely, the control group showed more microbleeds in the central brain (9 microbleeds, 60%, vs 3 microbleeds, 5%; p <0.0001). There was no statistical difference in number of microbleeds in the cerebellum and brainstem (p 0.2598 and p 0.4932, respectively). Patients with mTBI who had detected microbleeds had lower digit span scores than the patients with negative SWMRI findings (p 0.017). Conclusion: Presence of mTBI-related microbleeds showed a neuropsychological defect on short-term memory function, indicating that the presence of microbleeds could be a possible severity biomarker for mTBI. Addition of the SWMRI technique to the MRI protocol for patients with mTBI is recommended.

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