Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan

Shyun Yeu Liu, Chin Li Lu, Chang Ta Chiou, Ching Yu Yen, Gwo An Liaw, Yi Chun Chen, Yu Chi Liu, Wei Fan Chiang

研究成果: 雜誌貢獻文章

39 引文 (Scopus)

摘要

Oral squamous cell carcinoma (OSCC) is one of the most common cancers in geographic regions where betel quid (BQ) chewing is prevalent; OSCC is an extremely malignant neoplasm whose prognostic factors are multiple and complex. The purpose of this study was to assess clinicopathological prognostic factors and treatment outcomes in 698 consecutive OSCC patients who had undergone surgery as the primary treatment in an area with a high prevalence of both betel quid chewing and tobacco smoking. The prognostic factors were predicted using Cox's proportional-hazards regression model, and the survival rate was calculated using Kaplan-Meier analysis. The median followup for all patients was 44 months. The 5-year cumulative overall, disease-specific, and locoregional control survival rates were 61%, 62%, and 46%, respectively. Multivariate analysis showed that the lower level of nodal metastasis, advanced stage, tumor thickness >7 mm, and treatment failures were independent risk factors of overall survival. Furthermore, history of alcohol drinking, lower level of nodal metastasis, advanced stage, poor cell differentiation, and treatment failures were independent predictors of poor disease-specific survival. However, we did not find any significant factor that affected locoregional recurrence. Due to the high frequencies of locoregional recurrence and second primary cancer, our findings emphasize that aggressive surgical excision, adjuvant treatments according to clinicopathological prognostic factors and close surveillance are important to the survival of OSCC patients in an area with a high prevalence of betel quid chewing and tobacco smoking.
原文英語
頁(從 - 到)276-282
頁數7
期刊Oral Oncology
46
發行號4
DOIs
出版狀態已發佈 - 四月 2010
對外發佈Yes

指紋

Smokeless Tobacco
Mouth Neoplasms
Taiwan
Squamous Cell Carcinoma
Smoking
Treatment Failure
Survival
Survival Rate
Neoplasm Metastasis
Recurrence
Neoplasms
Second Primary Neoplasms
Mastication
Kaplan-Meier Estimate
Proportional Hazards Models
Alcohol Drinking
Cell Differentiation
Multivariate Analysis
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

引用此文

Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan. / Liu, Shyun Yeu; Lu, Chin Li; Chiou, Chang Ta; Yen, Ching Yu; Liaw, Gwo An; Chen, Yi Chun; Liu, Yu Chi; Chiang, Wei Fan.

於: Oral Oncology, 卷 46, 編號 4, 04.2010, p. 276-282.

研究成果: 雜誌貢獻文章

Liu, Shyun Yeu ; Lu, Chin Li ; Chiou, Chang Ta ; Yen, Ching Yu ; Liaw, Gwo An ; Chen, Yi Chun ; Liu, Yu Chi ; Chiang, Wei Fan. / Surgical outcomes and prognostic factors of oral cancer associated with betel quid chewing and tobacco smoking in Taiwan. 於: Oral Oncology. 2010 ; 卷 46, 編號 4. 頁 276-282.
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abstract = "Oral squamous cell carcinoma (OSCC) is one of the most common cancers in geographic regions where betel quid (BQ) chewing is prevalent; OSCC is an extremely malignant neoplasm whose prognostic factors are multiple and complex. The purpose of this study was to assess clinicopathological prognostic factors and treatment outcomes in 698 consecutive OSCC patients who had undergone surgery as the primary treatment in an area with a high prevalence of both betel quid chewing and tobacco smoking. The prognostic factors were predicted using Cox's proportional-hazards regression model, and the survival rate was calculated using Kaplan-Meier analysis. The median followup for all patients was 44 months. The 5-year cumulative overall, disease-specific, and locoregional control survival rates were 61{\%}, 62{\%}, and 46{\%}, respectively. Multivariate analysis showed that the lower level of nodal metastasis, advanced stage, tumor thickness >7 mm, and treatment failures were independent risk factors of overall survival. Furthermore, history of alcohol drinking, lower level of nodal metastasis, advanced stage, poor cell differentiation, and treatment failures were independent predictors of poor disease-specific survival. However, we did not find any significant factor that affected locoregional recurrence. Due to the high frequencies of locoregional recurrence and second primary cancer, our findings emphasize that aggressive surgical excision, adjuvant treatments according to clinicopathological prognostic factors and close surveillance are important to the survival of OSCC patients in an area with a high prevalence of betel quid chewing and tobacco smoking.",
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AU - Liaw, Gwo An

AU - Chen, Yi Chun

AU - Liu, Yu Chi

AU - Chiang, Wei Fan

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AB - Oral squamous cell carcinoma (OSCC) is one of the most common cancers in geographic regions where betel quid (BQ) chewing is prevalent; OSCC is an extremely malignant neoplasm whose prognostic factors are multiple and complex. The purpose of this study was to assess clinicopathological prognostic factors and treatment outcomes in 698 consecutive OSCC patients who had undergone surgery as the primary treatment in an area with a high prevalence of both betel quid chewing and tobacco smoking. The prognostic factors were predicted using Cox's proportional-hazards regression model, and the survival rate was calculated using Kaplan-Meier analysis. The median followup for all patients was 44 months. The 5-year cumulative overall, disease-specific, and locoregional control survival rates were 61%, 62%, and 46%, respectively. Multivariate analysis showed that the lower level of nodal metastasis, advanced stage, tumor thickness >7 mm, and treatment failures were independent risk factors of overall survival. Furthermore, history of alcohol drinking, lower level of nodal metastasis, advanced stage, poor cell differentiation, and treatment failures were independent predictors of poor disease-specific survival. However, we did not find any significant factor that affected locoregional recurrence. Due to the high frequencies of locoregional recurrence and second primary cancer, our findings emphasize that aggressive surgical excision, adjuvant treatments according to clinicopathological prognostic factors and close surveillance are important to the survival of OSCC patients in an area with a high prevalence of betel quid chewing and tobacco smoking.

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