Surface area as a dose metric for carbon black nanoparticles: A study of oxidative stress, DNA single-strand breakage and inflammation in rats

Hsiao Chi Chuang, Li Chen Chen, Yu Chen Lei, Kuen Yuh Wu, Po Hao Feng, Tsun Jen Cheng

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Combustion-derived nanoparticles are characterised by a high surface area (SA) per mass. SA is proposed to regulate the bioreactivity of nanoparticles; however, the dose metric for carbon black remains controversial. To determine the relationships between bioreactivity and SA, male spontaneously hypertensive rats were exposed to carbon black (CB) nanoparticles (15, 51 and 95nm) via intratracheal instillation for 24h. Pulmonary exposure to CB resulted in a significant increase in systemic 8-hydroxy-2'-deoxyguanosine (8-OHdG), DNA single-strand breakages in peripheral blood cells and pulmonary cell infiltration in rats. The oxidative potential and particularly the corresponding SA of CB were correlated with the level of 8-OHdG, DNA single-strand breakages and pulmonary cell infiltration in rats. We conclude that SA is an important dose metric for CB that can regulate oxidative stress and DNA damage in rats. Furthermore, this observation was more significant for smaller sized CB.
原文英語
頁(從 - 到)329-334
頁數6
期刊Atmospheric Environment
106
DOIs
出版狀態已發佈 - 四月 1 2015

指紋

black carbon
breakage
surface area
DNA
infiltration
oxidative stress
dose
nanoparticle
combustion
blood
damage

ASJC Scopus subject areas

  • Atmospheric Science
  • Environmental Science(all)

引用此文

Surface area as a dose metric for carbon black nanoparticles : A study of oxidative stress, DNA single-strand breakage and inflammation in rats. / Chuang, Hsiao Chi; Chen, Li Chen; Lei, Yu Chen; Wu, Kuen Yuh; Feng, Po Hao; Cheng, Tsun Jen.

於: Atmospheric Environment, 卷 106, 01.04.2015, p. 329-334.

研究成果: 雜誌貢獻文章

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AU - Wu, Kuen Yuh

AU - Feng, Po Hao

AU - Cheng, Tsun Jen

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AB - Combustion-derived nanoparticles are characterised by a high surface area (SA) per mass. SA is proposed to regulate the bioreactivity of nanoparticles; however, the dose metric for carbon black remains controversial. To determine the relationships between bioreactivity and SA, male spontaneously hypertensive rats were exposed to carbon black (CB) nanoparticles (15, 51 and 95nm) via intratracheal instillation for 24h. Pulmonary exposure to CB resulted in a significant increase in systemic 8-hydroxy-2'-deoxyguanosine (8-OHdG), DNA single-strand breakages in peripheral blood cells and pulmonary cell infiltration in rats. The oxidative potential and particularly the corresponding SA of CB were correlated with the level of 8-OHdG, DNA single-strand breakages and pulmonary cell infiltration in rats. We conclude that SA is an important dose metric for CB that can regulate oxidative stress and DNA damage in rats. Furthermore, this observation was more significant for smaller sized CB.

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KW - Surface area

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