Suppression of voltage-gated Na+ channels and neuronal excitability by imperatorin

King Chuen Wu, Yi Hung Chen, Ka Shun Cheng, Yueh Hsiung Kuo, Chin Tsang Yang, Kar Lok Wong, Yuan Kun Tu, Paul Chan, Yuk Man Leung

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

摘要

Imperatorin is a naturally occurring furocoumarin compound isolated from plants such as Angelica archangelica and Cnidium monnieri. It has multiple pharmacological effects including anticonvulsant effects. Here we determined the effects of imperatorin on voltage-gated Na+ channels (VGSC) using whole-cell patch clamp techniques in differentiated neuronal NG108-15 cells. We showed that imperatorin inhibited VGSC; such inhibition did not show state-dependence. Imperatorin caused a left shift in the steady-state inactivation curve without affecting activation gating. The inhibition of VGSC by imperatorin displayed a mild frequency-dependence. Imperatorin was also shown to inhibit VGSC and action potential amplitude without affecting voltage-gated K+ channels in rat hippocampal CA1 neurons. In conclusion, our results suggest that imperatorin dampens neuronal excitability by inhibiting VGSC.

原文英語
頁(從 - 到)49-55
頁數7
期刊European Journal of Pharmacology
721
發行號1-3
DOIs
出版狀態已發佈 - 十二月 5 2013

ASJC Scopus subject areas

  • Pharmacology

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  • 引用此

    Wu, K. C., Chen, Y. H., Cheng, K. S., Kuo, Y. H., Yang, C. T., Wong, K. L., Tu, Y. K., Chan, P., & Leung, Y. M. (2013). Suppression of voltage-gated Na+ channels and neuronal excitability by imperatorin. European Journal of Pharmacology, 721(1-3), 49-55. https://doi.org/10.1016/j.ejphar.2013.09.056