Sulfated non-anticoagulant heparins (S-NACHs) might be preferred for potential clinical use in cancer patients without affecting hemostasis as compared to low molecular weight heparins (LMWHs). We investigated anti-tumor effects, anti-angiogenesis effects, and mechanisms of S-NACH in a mouse model of pancreatic cancer as compared to the LMWH tinzaparin. S-NACH or tinzaparin with or without gemcitabine were administered, and tumor luminescent signal intensity, tumor weight, and histopathology were assessed at the termination of the study. S-NACH and LMWH efficiently inhibited tumor growth and metastasis, without any observed bleeding events with S-NACH as compared to tinzaparin. S-NACH distinctly increased tumor necrosis and enhanced gemcitabine response in the mouse pancreatic cancer models. These data suggest the potential implication of S-NACH as a neoadjuvant in pancreatic cancer.
ASJC Scopus subject areas
- Cancer Research
Sudha, T., Yalcin, M., Lin, H. Y., Elmetwally, A. M., Nazeer, T., Arumugam, T., Phillips, P., & Mousa, S. A. (2014). Suppression of pancreatic cancer by sulfated non-anticoagulant low molecular weight heparin. Cancer Letters, 350(1-2), 25-33. https://doi.org/10.1016/j.canlet.2014.04.016