Superoxide anion scavenge effect of querem glauca thunb. in whole blood of patients with ankylosing spondylitis

Shiow Yunn Sheu, Yang Hwei Tsuang, Feng Lin Hsu, Fung Jou Lu, Hsiich Ching Chiang

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Nine phenolic compounds, catechin (1), epicatechin (2), gallocatechin (3), epigallocatechin (4), procyanidin B-4 (5), catechin-3-O-rhamnoside (6), rutin (7), querglanin (8) and isoquerglanin (9) were isolated from oak leaves (Quercus glauca Thunb. Fagaceae). the latter two (8, 9) were identified as new compounds. Several Quercus species have been used in folk medicine as an astringent for hemorrhoids and for treatment of inflammation, jaundice. tumor. In this study, these compounds were tested for scavenging effects of the Superoxide anion in the whole blood of patients with ankylosing spondylitis by means of an ultra-sensitive chemoluminescence (CL) analyzer and lucigenin amplification. The results showed that at a concentration of 2.3 × 10-5 M, isoquerglanin (9) displayed the strongest inhibition activity (73.55%), followed by querglanin (8) (68.81 %) and then gallocatechin (3) and epigallocatechin (4) (66.97 and 60.17% inhibition, respectively). In addition, the blood chemoluminescence (CL) level of patients with ankylosing spondylitis was inhibited by Superoxide dismutase (SOD) but not by catalase, suggesting that Superoxide anion is the major component of reactive oxygen species (ROS) involved in this assay system.

原文英語
頁(從 - 到)307-315
頁數9
期刊American Journal of Chinese Medicine
25
發行號3-4
出版狀態已發佈 - 1997
對外發佈Yes

ASJC Scopus subject areas

  • Complementary and alternative medicine

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