SUMOylation of Blimp-1 is critical for plasma cell differentiation

Hsia Yuan Ying, Shin Tang Su, Pang Hung Hsu, Che Chang Chang, I. Ying Lin, Yu Hsuan Tseng, Ming Daw Tsai, Hsiu Ming Shih, Kuo I. Lin

研究成果: 雜誌貢獻文章同行評審

13 引文 斯高帕斯(Scopus)

摘要

Transcriptional repressor B lymphocyte-induced maturation protein-1 (Blimp-1) is a master regulator of plasma cell differentiation. Here we show that Blimp-1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp-1 lysine 816 reduces transcriptional repression-correlating with a reduced interaction with a histone deacetylase, HDAC2-and impairs differentiation of antibody-secreting cells. Thus, the SUMO pathway critically regulates Blimp-1 function during plasma cell differentiation.
原文英語
頁(從 - 到)631-637
頁數7
期刊EMBO Reports
13
發行號7
DOIs
出版狀態已發佈 - 七月 2012
對外發佈

ASJC Scopus subject areas

  • 遺傳學
  • 分子生物學
  • 生物化學

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