To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology
- Cell Biology
Dou, H., Huang, C., Van Nguyen, T., Lu, L. S., & Yeh, E. T. H. (2011). SUMOylation and de-SUMOylation in response to DNA damage. FEBS Letters, 585(18), 2891-2896. https://doi.org/10.1016/j.febslet.2011.04.002