SUMOylation and de-SUMOylation in response to DNA damage

Hong Dou, Chao Huang, Thang Van Nguyen, Long Sheng Lu, Edward T.H. Yeh

研究成果: 雜誌貢獻回顧型文獻

56 引文 斯高帕斯(Scopus)

摘要

To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
原文英語
頁(從 - 到)2891-2896
頁數6
期刊FEBS Letters
585
發行號18
DOIs
出版狀態已發佈 - 九月 16 2011
對外發佈Yes

Keywords

  • Repair
  • Replication
  • RPA
  • SENP
  • SUMO

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • 引用此

    Dou, H., Huang, C., Van Nguyen, T., Lu, L. S., & Yeh, E. T. H. (2011). SUMOylation and de-SUMOylation in response to DNA damage. FEBS Letters, 585(18), 2891-2896. https://doi.org/10.1016/j.febslet.2011.04.002