SUMOylation and de-SUMOylation in response to DNA damage

Hong Dou; Chao Huang; Thang Van Nguyen; Long Sheng Lu; Edward T.H. Yeh

doi:10.1016/j.febslet.2011.04.002

SUMOylation and de-SUMOylation in response to DNA damage

Hong Dou, Chao Huang, Thang Van Nguyen, Long Sheng Lu, Edward T.H. Yeh

研究成果: 雜誌貢獻 › 回顧型文獻 › 同行評審

65 引文斯高帕斯（Scopus）

摘要

To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).

原文	英語
頁（從 - 到）	2891-2896
頁數	6
期刊	FEBS Letters
卷	585
發行號	18
DOIs	https://doi.org/10.1016/j.febslet.2011.04.002
出版狀態	已發佈 - 9月 16 2011
對外發佈	是

Keywords

Repair
Replication
RPA
SENP
SUMO

ASJC Scopus subject areas

生物物理學
結構生物學
生物化學
分子生物學
遺傳學
細胞生物學

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10.1016/j.febslet.2011.04.002

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Link to publication in Scopus

引用此

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title = "SUMOylation and de-SUMOylation in response to DNA damage",

abstract = "To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).",

keywords = "Repair, Replication, RPA, SENP, SUMO, Repair, Replication, RPA, SENP, SUMO",

author = "Hong Dou and Chao Huang and {Van Nguyen}, Thang and Lu, {Long Sheng} and Yeh, {Edward T.H.}",

year = "2011",

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T1 - SUMOylation and de-SUMOylation in response to DNA damage

AU - Dou, Hong

AU - Huang, Chao

AU - Van Nguyen, Thang

AU - Lu, Long Sheng

AU - Yeh, Edward T.H.

PY - 2011/9/16

Y1 - 2011/9/16

N2 - To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).

AB - To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).

KW - Repair

KW - Replication

KW - RPA

KW - SENP

KW - SUMO

KW - Repair

KW - Replication

KW - RPA

KW - SENP

KW - SUMO

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DO - 10.1016/j.febslet.2011.04.002

M3 - Review article

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JF - FEBS Letters

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ER -

SUMOylation and de-SUMOylation in response to DNA damage

摘要

Keywords

ASJC Scopus subject areas

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