SUMOylation and de-SUMOylation in response to DNA damage

Hong Dou, Chao Huang, Thang Van Nguyen, Long Sheng Lu, Edward T.H. Yeh

研究成果: 雜誌貢獻回顧型文獻同行評審

65 引文 斯高帕斯(Scopus)

摘要

To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
原文英語
頁(從 - 到)2891-2896
頁數6
期刊FEBS Letters
585
發行號18
DOIs
出版狀態已發佈 - 9月 16 2011
對外發佈

Keywords

  • Repair
  • Replication
  • RPA
  • SENP
  • SUMO

ASJC Scopus subject areas

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

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