摘要
To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin-like modifier) can regulate protein stability, protein cellular location, and protein-protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de-SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
原文 | 英語 |
---|---|
頁(從 - 到) | 2891-2896 |
頁數 | 6 |
期刊 | FEBS Letters |
卷 | 585 |
發行號 | 18 |
DOIs | |
出版狀態 | 已發佈 - 9月 16 2011 |
對外發佈 | 是 |
Keywords
- Repair
- Replication
- RPA
- SENP
- SUMO
ASJC Scopus subject areas
- 生物物理學
- 結構生物學
- 生物化學
- 分子生物學
- 遺傳學
- 細胞生物學