SUMO-Specific Protease 1 Is Critical for Early Lymphoid Development through Regulation of STAT5 Activation

Thang Van Nguyen, Pornpimon Angkasekwinai, Hong Dou, Feng Ming Lin, Long Sheng Lu, Jinke Cheng, Y. Eugene Chin, Chen Dong, Edward T H Yeh

研究成果: 雜誌貢獻文章同行評審

74 引文 斯高帕斯(Scopus)

摘要

Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 inthe regulation of STAT5 activation during early lymphoid development.
原文英語
頁(從 - 到)210-221
頁數12
期刊Molecular Cell
45
發行號2
DOIs
出版狀態已發佈 - 1月 27 2012
對外發佈

ASJC Scopus subject areas

  • 分子生物學
  • 細胞生物學

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