SUMO modification modulates the transrepression activity of PLZF

Ting Ting Chao, Che Chang Chang, Hsiu Ming Shih

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Small ubiquitin-like modifier (SUMO) modification has recently been shown to associate with transcriptional regulation and nuclear body formation. Here, we show that transcription factor PLZF can be SUMO modified at lysine residue 242, 387 and 396. Converting these three SUMO acceptor Lys to Arg 3KR does not significantly affect PLZF nuclear body formation, which is distinct from the scenario of PML sumoylation in PML nuclear body formation. Furthermore, PLZF-3KR markedly reduced the transcriptional repression activity, correlating with a loss of PLZF-mediated growth suppression. These results reveal an important role of SUMO modification in PLZF-mediated transcriptional repression.
原文英語
頁(從 - 到)475-482
頁數8
期刊Biochemical and Biophysical Research Communications
358
發行號2
DOIs
出版狀態已發佈 - 6月 29 2007
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 生物化學
  • 分子生物學
  • 細胞生物學

指紋

深入研究「SUMO modification modulates the transrepression activity of PLZF」主題。共同形成了獨特的指紋。

引用此