Successful treatment of life-threatening melioidosis with activated protein C and meropenem

Che Kim Tan, Khee Siang Chan, Wen-Liang Yu, Chin Ming Chen, Kuo Chen Cheng

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

Melioidosis is an endemic disease in southeast Asia and northern Australia, caused by Burkholderia pseudomallei. A typhoon-related outbreak occurred in southern Taiwan in July 2005. High mortality in melioidosis associated with bacteremic pneumonia and septic shock. We report a patient with life-threatening melioidosis who developed rapid progression of bacteremic pneumonia with acute respiratory distress syndrome, septic shock and multiple organ dysfunction and was successfully treated with recombinant human activated protein C (rhAPC) and meropenem. Although rhAPC has been reported to reduce the mortality of severe septic shock caused by various pathogens, to our best knowledge, this is the first reported case of rhAPC application in life-threatening melioidosis.

原文英語
頁(從 - 到)83-87
頁數5
期刊Journal of Microbiology, Immunology and Infection
40
發行號1
出版狀態已發佈 - 二月 2007
對外發佈Yes

指紋

meropenem
Melioidosis
Protein C
Septic Shock
Pneumonia
Burkholderia pseudomallei
Cyclonic Storms
Endemic Diseases
Southeastern Asia
Mortality
Adult Respiratory Distress Syndrome
Therapeutics
Taiwan
Disease Outbreaks

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

引用此文

Successful treatment of life-threatening melioidosis with activated protein C and meropenem. / Tan, Che Kim; Chan, Khee Siang; Yu, Wen-Liang; Chen, Chin Ming; Cheng, Kuo Chen.

於: Journal of Microbiology, Immunology and Infection, 卷 40, 編號 1, 02.2007, p. 83-87.

研究成果: 雜誌貢獻文章

Tan, Che Kim ; Chan, Khee Siang ; Yu, Wen-Liang ; Chen, Chin Ming ; Cheng, Kuo Chen. / Successful treatment of life-threatening melioidosis with activated protein C and meropenem. 於: Journal of Microbiology, Immunology and Infection. 2007 ; 卷 40, 編號 1. 頁 83-87.
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