Successful treatment of an extensive verrucous carcinoma with topical 5-aminolevulinic acid-mediated photodynamic therapy

Hsin Ming Chen, Chin Tin Chen, Hsiang Yang, Ming I. Lee, Mark Yen Ping Kuo, Ying Shiung Kuo, Yi Ping Wang, Tsuimin Tsai, Chun Pin Chiang

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51 引文 斯高帕斯(Scopus)

摘要

Our recent study found that a new topical 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) protocol composed of multiple 3-min fractionated irradiations with a light emitting diode (LED) red light at 635 ± 5 nm for a total of 1000 s (fluence rate: 100 mW/cm2; light exposure dose: 100 J/cm2) after topical application of 20% ALA for 1.5 or 2 h can be used successfully for the treatment of oral verrucous hyperplasia. In this case report, we tested the efficacy of this new treatment protocol of ALA-PDT for an extraoral verrucous carcinoma (VC) lesion at the right mouth angle and an intraoral VC lesion at the right buccal mucosa of a 56-year-old male areca quid chewer and smoker. The extraoral tumor was cleared after six treatments of topical ALA-PDT and the intraoral tumor showed complete regression after 22 treatments of topical ALA-PDT. No recurrence of the VC lesion was found after a follow-up period of 6 months. We suggest that FDT using a topical application of 20% ALA followed by multiple 3-min fractionated irradiations with an LED red light is also an effective and successful treatment modality for VC.

原文英語
頁(從 - 到)253-256
頁數4
期刊Journal of Oral Pathology and Medicine
34
發行號4
DOIs
出版狀態已發佈 - 4月 2005

ASJC Scopus subject areas

  • 癌症研究
  • 病理學與法醫學
  • 牙科 (全部)

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