Successful allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in a patient with severe aplastic anemia and active infection

Tso Fu Wang, Yi Feng Wu, Yu Huai Ho, Shih Che Huang, Sung Chao Chu, Ruey Ho Kao

研究成果: 雜誌貢獻文章

摘要

Infection is the major cause of mortality in patients with severe aplastic anemia (SAA) and often results in postponement of immunotherapy or transplantation treatment. We report on a 23-year-old man with very SAA with almost no neutrophils who was primarily treated with peripheral blood stem cell transplantation from an HLA-identical sibling. He received reduced dose conditioning with cyclophosphamide and antithymocyte globulin during active infection with typhlitis and pneumonia. Cyclophosphamide 50. mg/kg/d was given on Day 4 and Day 3 before transplantation and antithymocyte globulin Fresenius 20. mg/kg/d was given on Day 3 and Day 2. Neutrophils and platelets were engrafted on Day +18 and Day +20 after transplantation. Symptoms and signs of acute or chronic graft versus host disease were not observed as of Day +545 after transplantation. Allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning may be considered as the primary therapy for SAA complicated by severe infection.
原文英語
頁(從 - 到)100-102
頁數3
期刊Tzu Chi Medical Journal
23
發行號3
DOIs
出版狀態已發佈 - 九月 1 2011
對外發佈Yes

指紋

Peripheral Blood Stem Cell Transplantation
Aplastic Anemia
Transplantation
Antilymphocyte Serum
Infection
Cyclophosphamide
Typhlitis
Neutrophils
Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
Immunotherapy
Signs and Symptoms
Siblings
Pneumonia
Blood Platelets
Mortality
Conditioning (Psychology)
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Successful allogeneic peripheral blood stem cell transplantation with reduced intensity conditioning in a patient with severe aplastic anemia and active infection. / Wang, Tso Fu; Wu, Yi Feng; Ho, Yu Huai; Huang, Shih Che; Chu, Sung Chao; Kao, Ruey Ho.

於: Tzu Chi Medical Journal, 卷 23, 編號 3, 01.09.2011, p. 100-102.

研究成果: 雜誌貢獻文章

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AU - Kao, Ruey Ho

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