Study the property of double-ended fluoroalkyl poly(ethylene glycol) hydrogel as a depot for hydrophobic drug delivery using electron paramagnetic resonance technique and cell proliferation assay

Xiangli Liu, Yougang Mao, Errol V. Mathias, Collin Ma, Osmundo Franco, Yong Ba, Julia A. Kornfield, Tieli Wang, Lijun Xue, Bing Sen Zhou, Yun Yen

研究成果: 雜誌貢獻文章同行評審

6 引文 斯高帕斯(Scopus)

摘要

Hydrogel formed by fluoroalkyl double-ended polyethylene glycol (R f-PEG) micelles was studied to assess its properties to encapsulate a hydrophobic electron spin labeled drug, Chlorambucil-Tempol adduct (CT), and to control and sustain the drug release. The drug loaded hydrogel samples were characterized with variable-temperature dependent EPR experiment, and EPR theoretical lineshape analysis. It was found that CT molecules reside in the hydrophobic Rf-cores/IPDU shells of the Rf-PEG micelles and the maximum molecular-level loading capacity was estimated to be 18.8 mg per gram of the Rf-PEG. It has been known that Rf-PEG hydrogel with certain molecular masses for the fluoroalkyl group and the PEG chain shows properties of sol/gel phase coexistence and surface erosion, which represent the favorable condition for a pharmaceutical depot to control the kinetics of drug release. To evaluate the Rf-PEG's biocompatibility and kinetics of the drug release, a cell proliferation assay was carried out on human oropharyngeal carcinoma (KB) cells. The results show that R f-PEG is biocompatible and able to release CT to the cell media with a constant equilibrium concentration independent of the amount of CT loaded hydrogel.

原文英語
頁(從 - 到)269-278
頁數10
期刊Journal of Sol-Gel Science and Technology
45
發行號3
DOIs
出版狀態已發佈 - 三月 1 2008
對外發佈

ASJC Scopus subject areas

  • 電子、光磁材料
  • 陶瓷和複合材料
  • 化學 (全部)
  • 生物材料
  • 凝聚態物理學
  • 材料化學

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