Study on the stevioside analogues of steviolbioside, steviol, and isosteviol 19-alkyl amide dimers: Synthesis and cytotoxic and antibacterial activity

Lun Huei Lin, Lin Wen Lee, Shiow Yunn Sheu, Pen Yuan Lin

研究成果: 雜誌貢獻文章同行評審

48 引文 斯高帕斯(Scopus)

摘要

A new group of steviolbioside amide dimers 2a - g, derivatives 2h - i and their related steviol and isosteviol amide dimers 3a and 4a were prepared by reacting aliphatic alkylamine and alkyldiamines with PyBOP and DIEA. The synthesized compounds had cytotoxic effects on cancer and human embryonic lung cells. Compounds 3a, 4a, 2b and 2h were cytotoxic to cancer cells and to a lesser extent to human embryo lung cells. Compounds 2f, 2g and 4 of this series had favorable antibacterial effects, and were superior to penicillin G at inhibiting growth of Bacillus subtilis (BCRC 10029). The cytotoxicity and antibacterial effects may depend on the dimerization and derivative moieties in relation to the respective aglycons.

原文英語
頁(從 - 到)1117-1122
頁數6
期刊Chemical and Pharmaceutical Bulletin
52
發行號9
DOIs
出版狀態已發佈 - 九月 2004

ASJC Scopus subject areas

  • 藥物發現
  • 有機化學
  • 化學 (全部)
  • 藥理

指紋

深入研究「Study on the stevioside analogues of steviolbioside, steviol, and isosteviol 19-alkyl amide dimers: Synthesis and cytotoxic and antibacterial activity」主題。共同形成了獨特的指紋。

引用此