摘要
The effects of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel on microspheres preparation or drug release were studied. The rate of gelation is zero order corresponding to the chitosan concentration but non-zero order corresponding to the glutaraldehyde concentration. It was suggested that the cross-linking reaction was mainly dominated by the concentration of small molecule reactant, glutaraldehyde. The relaxation of an entangled polymer chain in a gel network as a result of the swelling of cross-linked chitosan hydrogel was investigated by the stress-strain determination. The higher the cross-linking density of chitosan hydrogel, the lower the swelling ability of chitosan hydrogel due to the slower relaxation rate of polymer chain, which then results in the decreased drug-release rate.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 389-396 |
| 頁數 | 8 |
| 期刊 | Carbohydrate Polymers |
| 卷 | 41 |
| 發行號 | 4 |
| DOIs | |
| 出版狀態 | 已發佈 - 四月 2000 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Food Science
- Biochemistry
引用此文
Study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release. / Mi, Fwu Long; Kuan, Chih Yang; Shyu, Shin Shing; Lee, Sung T.; Chang, Shon Foun.
於: Carbohydrate Polymers, 卷 41, 編號 4, 04.2000, p. 389-396.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release
AU - Mi, Fwu Long
AU - Kuan, Chih Yang
AU - Shyu, Shin Shing
AU - Lee, Sung T.
AU - Chang, Shon Foun
PY - 2000/4
Y1 - 2000/4
N2 - The effects of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel on microspheres preparation or drug release were studied. The rate of gelation is zero order corresponding to the chitosan concentration but non-zero order corresponding to the glutaraldehyde concentration. It was suggested that the cross-linking reaction was mainly dominated by the concentration of small molecule reactant, glutaraldehyde. The relaxation of an entangled polymer chain in a gel network as a result of the swelling of cross-linked chitosan hydrogel was investigated by the stress-strain determination. The higher the cross-linking density of chitosan hydrogel, the lower the swelling ability of chitosan hydrogel due to the slower relaxation rate of polymer chain, which then results in the decreased drug-release rate.
AB - The effects of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel on microspheres preparation or drug release were studied. The rate of gelation is zero order corresponding to the chitosan concentration but non-zero order corresponding to the glutaraldehyde concentration. It was suggested that the cross-linking reaction was mainly dominated by the concentration of small molecule reactant, glutaraldehyde. The relaxation of an entangled polymer chain in a gel network as a result of the swelling of cross-linked chitosan hydrogel was investigated by the stress-strain determination. The higher the cross-linking density of chitosan hydrogel, the lower the swelling ability of chitosan hydrogel due to the slower relaxation rate of polymer chain, which then results in the decreased drug-release rate.
UR - http://www.scopus.com/inward/record.url?scp=0034174051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034174051&partnerID=8YFLogxK
U2 - 10.1016/S0144-8617(99)00104-6
DO - 10.1016/S0144-8617(99)00104-6
M3 - Article
AN - SCOPUS:0034174051
VL - 41
SP - 389
EP - 396
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
SN - 0144-8617
IS - 4
ER -