Study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release

Fwu Long Mi, Chih Yang Kuan, Shin Shing Shyu, Sung T. Lee, Shon Foun Chang

研究成果: 雜誌貢獻文章同行評審

157 引文 斯高帕斯(Scopus)

摘要

The effects of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel on microspheres preparation or drug release were studied. The rate of gelation is zero order corresponding to the chitosan concentration but non-zero order corresponding to the glutaraldehyde concentration. It was suggested that the cross-linking reaction was mainly dominated by the concentration of small molecule reactant, glutaraldehyde. The relaxation of an entangled polymer chain in a gel network as a result of the swelling of cross-linked chitosan hydrogel was investigated by the stress-strain determination. The higher the cross-linking density of chitosan hydrogel, the lower the swelling ability of chitosan hydrogel due to the slower relaxation rate of polymer chain, which then results in the decreased drug-release rate.

原文英語
頁(從 - 到)389-396
頁數8
期刊Carbohydrate Polymers
41
發行號4
DOIs
出版狀態已發佈 - 四月 2000
對外發佈

ASJC Scopus subject areas

  • 食品科學
  • 生物化學

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