Studies of photokilling of bacteria using titanium dioxide nanoparticles

Yang Hwei Tsuang, Jui Sheng Sun, Yu Chen Huang, Chung Hsin Lu, Walter Hong Shong Chang, Chien Che Wang

研究成果: 雜誌貢獻文章同行評審

180 引文 斯高帕斯(Scopus)

摘要

Metal pins used to apply skeletal traction or external fixation devices protruding through skin are susceptible to the increased incidence of pin site infection. In this work, we tried to establish the photokilling effects of titanium dioxide (TiO2) nanoparticles on an orthopedic implant with an in vitro study. In these photocatalytic experiments, aqueous TiO2 was added to the tested microorganism. The time effect of TiO2 photoactivation was evaluated, and the loss of viability of five different bacteria suspensions (Escherichia coli, Pseudomonas aeruginosa, Staphylococus aureus, Enterococcus hirae, and Bacteroides fragilis) was examined by the viable count procedure. The bactericidal effect of TiO2 nanoparticle-coated metal plates was also tested. The ultraviolet (UV) dosage used in this experiment did not affect the viability of bacteria, and all bacteria survived well in the absence of TiO2 nanoparticles. The survival curve of microorganisms in the presence of TiO2 nanoparticles showed that nearly complete killing was achieved after 50 min of UV illumination. The formation of bacterial colonies above the TiO2 nanoparticle-coated metal plates also decreased significantly. In this study, we clearly demonstrated the bactericidal effects of titanium dioxide nanoparticles. In the presence of UV light, the titanium dioxide nanoparticles can be applicable to medical facilities where the potential for infection should be controlled.

原文英語
頁(從 - 到)167-174
頁數8
期刊Artificial Organs
32
發行號2
DOIs
出版狀態已發佈 - 2月 2008
對外發佈

ASJC Scopus subject areas

  • 生物工程
  • 醫藥(雜項)
  • 生物材料
  • 生物醫學工程

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