Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense

Yves S.Y. Hsieh, Cheng Chien, Sylvian K.S. Liao, Shih Fen Liao, Wei Ting Hung, Wen Bin Yang, Chih Chien Lin, Ting Jen Rachel Cheng, Chia Chuan Chang, Jim Min Fang, Chi Huey Wong

研究成果: 雜誌貢獻文章同行評審

120 引文 斯高帕斯(Scopus)

摘要

Detailed structures of the active polysaccharides extracted from the leaf and stem cell walls and mucilage of Dendrobium huoshanense are determined by using various techniques, including chromatographic, spectroscopic, chemical, and enzymatic methods. The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-γ, IL-10, IL-6, and IL-1α, as well as hematopoietic growth factors GM-CSF and G-CSF. However, the deacetylated mucilage obtained from an alkaline treatment fails to induce cytokine production. The structure and bioactivity of mucilage components are validated by further fractionation. This is the first study that provides clear evidence for the structure and activity relationship of the polysaccharide in D. huoshanense.

原文英語
頁(從 - 到)6054-6068
頁數15
期刊Bioorganic and Medicinal Chemistry
16
發行號11
DOIs
出版狀態已發佈 - 六月 1 2008
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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