摘要
A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.
原文 | 英語 |
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頁(從 - 到) | 2871-2876 |
頁數 | 6 |
期刊 | Bioorganic and Medicinal Chemistry Letters |
卷 | 4 |
發行號 | 24 |
DOIs | |
出版狀態 | 已發佈 - 12月 22 1994 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 生物化學
- 分子生物學
- 有機化學
- 藥物發現
- 藥學科學