Structure activity of topoisomerase i poisons related to hoechst 33342

Qun Sun; Barbra Gatto; Chiang Yu; Angela Liu; Leroy-Fong Liu; Edmond J. LaVoie

doi:10.1016/S0960-894X(01)80831-3

Structure activity of topoisomerase i poisons related to hoechst 33342

Qun Sun, Barbra Gatto, Chiang Yu, Angela Liu, Leroy-Fong Liu, Edmond J. LaVoie

研究成果: 雜誌貢獻 › 文章 › 同行評審

57 引文斯高帕斯（Scopus）

摘要

A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.

原文	英語
頁（從 - 到）	2871-2876
頁數	6
期刊	Bioorganic and Medicinal Chemistry Letters
卷	4
發行號	24
DOIs	https://doi.org/10.1016/S0960-894X(01)80831-3
出版狀態	已發佈 - 十二月 22 1994
對外發佈	是

ASJC Scopus subject areas

生物化學
分子生物學
有機化學
藥物發現
藥學科學

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10.1016/S0960-894X(01)80831-3

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Structure activity of topoisomerase i poisons related to hoechst 33342

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