Structure activity of topoisomerase i poisons related to hoechst 33342

Qun Sun, Barbra Gatto, Chiang Yu, Angela Liu, Leroy-Fong Liu, Edmond J. LaVoie

研究成果: 雜誌貢獻文章同行評審

57 引文 斯高帕斯(Scopus)

摘要

A series of bisbenzimidazoles related to Hoechst 33342 were synthesized. Data on the relative activity of these bisbenzimidazoles as topoisomerase I poisons suggest that considerable flexibility exists in the location of the tertiary alkylamine moeity. With the exception of arylamine analogs, cytotoxicity was generally consistent with their relative potency as topoisomerase I poisons.

原文英語
頁(從 - 到)2871-2876
頁數6
期刊Bioorganic and Medicinal Chemistry Letters
4
發行號24
DOIs
出版狀態已發佈 - 十二月 22 1994
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 分子生物學
  • 有機化學
  • 藥物發現
  • 藥學科學

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