Structural isomers and binding sites of guanine-rich quadruplexes investigated by induced circular dichroism of thionin: Loops and tails

Jin Yi Wu, Cheng Chung Chang, Cheng Sheng Yan, Kuan Yu Chen, I. Chun Kuo, Chung Yuan Mou, Ta Chau Chang

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Induced circular dichroism has been used to study the binding of thionin molecule to twelve guanine-rich quadruplexes. Substituting the base in the loops and varying the length of the tails could substantial change the induced circular dichroism spectra, which allow us to distinguish structural isomers and to determine the binding sites of quadruplexes. Our results show that external stacking on the end surface of the G-quartet associated with electrostatic interaction with the loops or tails is the major binding mode of thionin with these G-quadruplexes.

原文英語
頁(從 - 到)135-140
頁數6
期刊Journal of Biomolecular Structure and Dynamics
21
發行號1
DOIs
出版狀態已發佈 - 8月 2003
對外發佈

ASJC Scopus subject areas

  • 結構生物學
  • 分子生物學

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