Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors

Cheng Chung Lee, Chih Jung Kuo, Min Feng Hsu, Po Huang Liang, Jim Min Fang, Jiun Jie Shie, Andrew H.J. Wang

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)

摘要

Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg2+-PMA is coordinated to C44, M49 and Y54 with a square planar geometry at the S3 pocket, whereas each Zn2+ of the four zinc-inhibitors is tetrahedrally coordinated to the H41-C145 catalytic dyad. For anti-SARS drug design, this Zn2+-centered coordination pattern would serve as a starting platform for inhibitor optimization.
原文英語
頁(從 - 到)5454-5458
頁數5
期刊FEBS Letters
581
發行號28
DOIs
出版狀態已發佈 - 11月 27 2007
對外發佈

ASJC Scopus subject areas

  • 生物物理學
  • 結構生物學
  • 生物化學
  • 分子生物學
  • 遺傳學
  • 細胞生物學

指紋

深入研究「Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors」主題。共同形成了獨特的指紋。

引用此