Structural and functional analysis of a new cytokine, ML-1 (interleukin-17F)

Mio Kawaguchi, Mitsuru Adachi, Shau Ku Huang

研究成果: 雜誌貢獻回顧型文獻

7 引文 斯高帕斯(Scopus)

摘要

Recent large-scale sequencing of the human genome has facilitated novel gene discovery. A novel gene, ML-1 (interleukin (IL)-17F), was identified from a human expressed sequence tag (EST) sequence, a genomic DNA clone and T cell cDNA sequences. It was found that ML-1 shares significant sequence identity and functional similarity with the gene encoding IL-17A, but a distinct functional property for ML-1 has been demonstrated. While limited information is currently available, recent functional studies have suggested that ML-1 (IL-17F) is a multifunctional protein with a wide tissue expression pattern. In particular, the potent proinflammatory action of ML-1 (IL-17F) identified thus far, together with its association with asthma, suggests that ML-1 (IL-17F) may have a significant role in the regulation of airway inflammatory processes.

原文英語
頁(從 - 到)117-122
頁數6
期刊Allergology International
52
發行號3
DOIs
出版狀態已發佈 - 一月 1 2003
對外發佈Yes

ASJC Scopus subject areas

  • Immunology and Allergy

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