Streptococcal pyrogenic exotoxin B antibodies in a mouse model of glomerulonephritis

Y. H. Luo, C. F. Kuo, K. J. Huang, J. J. Wu, H. Y. Lei, M. T. Lin, W. J. Chuang, C. C. Liu, C. F. Lin, Y. S. Lin

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16 引文 斯高帕斯(Scopus)

摘要

Streptococcal pyrogenic exotoxin B is an extracellular cysteine protease. Only nephritis-associated strains of group A streptococci secrete this protease and this may be involved in the pathogenesis of post-streptococcal glomerulonephritis. Mice were actively immunized with a recombinant protease inactive exotoxin B mutant or passively immunized with exotoxin B antibody. Characteristics of glomerulonephritis were measured using histology, immunoglobulin deposition, complement activation, cell infiltration, and proteinuria. None of the mice given bovine serum albumin or exotoxin A as controls showed any marked changes. Immunoglobulin deposition, complement activation, and leukocyte infiltration occurred only in the glomeruli of exotoxin B-hyperimmunized mice. One particular anti-exotoxin B monoclonal antibody, 10G, was cross-reactive with kidney endothelial cells and it caused kidney injury and proteinuria when infused into mice. This cross-reactivity may be involved in the pathogenesis of glomerulonephritis following group A streptococcal infection.

原文英語
頁(從 - 到)716-724
頁數9
期刊Kidney International
72
發行號6
DOIs
出版狀態已發佈 - 9月 2007
對外發佈

ASJC Scopus subject areas

  • 腎臟病學

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