Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Yu Jung Lin, Fwu Long Mi, Po Yen Lin, Yang Bao Miao, Tringyo Huang, Kuan Hung Chen, Chiung Tong Chen, Yen Chang, Hsing Wen Sung

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.
原文英語
頁(從 - 到)71-82
頁數12
期刊Advanced Drug Delivery Reviews
139
DOIs
出版狀態已發佈 - 一月 15 2019

ASJC Scopus subject areas

  • 藥學科學

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