@article{dc34004e7bff4ba9a4da34c138dee72f,
title = "Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems",
abstract = "The encapsulation of insulin in micro- or nanodelivery systems may eliminate the need for frequent subcutaneous injections, improving the quality of life of diabetic patients. Formulations for oral, intranasal, pulmonary, subcutaneous, and transdermal administration have been developed. The use of stimuli-responsive polymeric carriers that can release the encapsulated drug in response to changes of the environmental stimuli or external activation enables the design of less invasive or non-invasive systems for smart insulin delivery from depots in the body. This article will look at strategies for the development of responsive delivery systems and the future meeting of the demands of new modes of insulin delivery.",
keywords = "Alternative routes, Diabetes mellitus, Glucose sensing, Insulin delivery, Stimuli-responsiveness",
author = "Lin, {Yu Jung} and Mi, {Fwu Long} and Lin, {Po Yen} and Miao, {Yang Bao} and Tringyo Huang and Chen, {Kuan Hung} and Chen, {Chiung Tong} and Yen Chang and Sung, {Hsing Wen}",
note = "Funding Information: The authors would like to thank the Ministry of Science and Technology ( MOST 107-2119-M-007-016 ) and the Ministry of Education ( MOE 107QR001I5 ) of Taiwan, ROC for financially supporting this research. Funding Information: The authors would like to thank the Ministry of Science and Technology (MOST 107-2119-M-007-016) and the Ministry of Education (MOE 107QR001I5) of Taiwan, ROC for financially supporting this research. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V.",
year = "2019",
month = jan,
day = "15",
doi = "10.1016/j.addr.2018.12.001",
language = "English",
volume = "139",
pages = "71--82",
journal = "Advanced Drug Delivery Reviews",
issn = "0169-409X",
publisher = "Elsevier",
}
