Stochastic model for non-standard case-cohort design

Tony Hsiu Hsi Chen, Ming Fang Yen, Ming Neng Shiu, Tao Hsin, Hui Min Wu

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Application of case-cohort design to multi-state disease progression in epidemiological studies has been barely addressed. To estimate multi-state disease natural history, we proposed non-homogeneous exponential regression stochastic model to accommodate the data requiring a non-standard case-cohort design. We allowed transition rates to vary with time by modelling the time of transitions between two states with Weibull distribution. The exponential regression model was used to assess the effect of patient-specific covariates on multi-state disease progressions. This method was successfully applied to two epidemiological applications. The first application was to elucidate the effect of betel quids, smoking and alcohol on three-state disease progression, from normal, through leukoplakia and finally to oral cancer. The second application was to extend the three-state to a five-state model to estimate transition rates from normal to diminutive adenoma to small adenoma to large adenoma and finally to invasive carcinoma of the colon and rectum. Finally, an index for assessing the treatment efficacy for pre-cancerous lesion was developed by comparing transition probabilities derived from the proposed model with the probabilities of malignant transformation after a medical regime.
原文英語
頁(從 - 到)633-647
頁數15
期刊Statistics in Medicine
23
發行號4
DOIs
出版狀態已發佈 - 二月 28 2004
對外發佈Yes

指紋

Case-cohort Design
Adenoma
Multi-state
Stochastic Model
Disease Progression
Progression
Leukoplakia
Regression Model
Mouth Neoplasms
Natural History
Rectum
Exponential Model
Epidemiologic Studies
Smoking
Weibull Distribution
Colon
Alcohol
Transition Probability
Alcohols
Estimate

ASJC Scopus subject areas

  • Epidemiology

引用此文

Chen, T. H. H., Yen, M. F., Shiu, M. N., Hsin, T., & Wu, H. M. (2004). Stochastic model for non-standard case-cohort design. Statistics in Medicine, 23(4), 633-647. https://doi.org/10.1002/sim.1610

Stochastic model for non-standard case-cohort design. / Chen, Tony Hsiu Hsi; Yen, Ming Fang; Shiu, Ming Neng; Hsin, Tao; Wu, Hui Min.

於: Statistics in Medicine, 卷 23, 編號 4, 28.02.2004, p. 633-647.

研究成果: 雜誌貢獻文章

Chen, THH, Yen, MF, Shiu, MN, Hsin, T & Wu, HM 2004, 'Stochastic model for non-standard case-cohort design', Statistics in Medicine, 卷 23, 編號 4, 頁 633-647. https://doi.org/10.1002/sim.1610
Chen, Tony Hsiu Hsi ; Yen, Ming Fang ; Shiu, Ming Neng ; Hsin, Tao ; Wu, Hui Min. / Stochastic model for non-standard case-cohort design. 於: Statistics in Medicine. 2004 ; 卷 23, 編號 4. 頁 633-647.
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