Stimulatory effect of D-ephedrine on β3-adrenoceptors in adipose tissue of rats

Juei Tang Cheng, I. Min Liu, Shi Ting Yen, Shiow Wen Juang, Tsang Pai Liu, Paul Chan

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)


The effect of ephedrine on β3-adrenoceptors (β3-AR) was studied in the isolated adipose tissue of Wistar rat. Incubation with D-ephedrine (0.1-10 μM) induced a concentration-dependent decrease of uptake of [14C]-deoxy-D-glucose into white adipose tissues (WAT). The inhibitory effect of D-ephedrine was potentiated by BRL 37344, the agonist of β3-AR and concentration-dependently inhibited by SR 59230A, the selective antagonist of β3-AR. The action of D-ephedrine on β3-AR was further blocked by the antibodies for β3-AR, but not the immunoglobulin, in a concentration-dependent manner. Moreover, D-ephedrine increased glycerol release from the isolated brown adipose tissues (BAT) and this action was also abolished by SR 59230A at concentration sufficient to block β3-AR. Thus, these results suggest that D-ephedrine has the ability to activate β3-AR both in WAT and BAT of Wistar rats in vitro.

頁(從 - 到)1-5
期刊Autonomic Neuroscience: Basic and Clinical
出版狀態已發佈 - 4月 12 2001

ASJC Scopus subject areas

  • 內分泌和自主系統
  • 神經病學(臨床)
  • 細胞與分子神經科學


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