Stimulation of prostaglandin E2 biosynthesis by estradiol in rat kidneys

研究成果: 雜誌貢獻文章

5 引文 (Scopus)

摘要

The effect of estradiol administration on renal prostaglandin (PG) E2 biosynthetic activity in rats was studied. A specific radioimmunoassay for PGE2 was developed and applied in the quantitation of PGE2 biosynthesis in kidney. Conversion of exogenous arachidonic acid into PGE2 by renal microsomal fraction was assayed. Formation of PGE2 was linear in fashion up to 5 min incubation at 37°C, and linear in fashion up to 3.5 mg of microsome used as enzyme source. The renal biosynthesis of PGE2 was significantly increased by estradiol treatment.

原文英語
頁(從 - 到)159-163
頁數5
期刊Prostaglandins Leukotrienes and Essential Fatty Acids
33
發行號3
出版狀態已發佈 - 1988
對外發佈Yes

指紋

Biosynthesis
Dinoprostone
Rats
Estradiol
Kidney
Microsomes
Arachidonic Acid
Radioimmunoassay
Enzymes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism

引用此文

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abstract = "The effect of estradiol administration on renal prostaglandin (PG) E2 biosynthetic activity in rats was studied. A specific radioimmunoassay for PGE2 was developed and applied in the quantitation of PGE2 biosynthesis in kidney. Conversion of exogenous arachidonic acid into PGE2 by renal microsomal fraction was assayed. Formation of PGE2 was linear in fashion up to 5 min incubation at 37°C, and linear in fashion up to 3.5 mg of microsome used as enzyme source. The renal biosynthesis of PGE2 was significantly increased by estradiol treatment.",
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