Stimulation of prostaglandin cyclooxygenase and prostacyclin synthetase activities by estradiol in rat aortic smooth muscle cells

Chang Wen-Chang, Nakao Junko, Orimo Hajime, Murota Sei-Itsu

研究成果: 雜誌貢獻文章同行評審

114 引文 斯高帕斯(Scopus)

摘要

The effects of estradiol on the arachidonic acid pool and prostacyclin biosynthetic activity in rat aortic smooth muscle cells were studied. Estradiol has no significant effect on the distribution of [14C] arachidonic acid in cells with respect to prostacyclin production assay, the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and cellular phospholipase (or/and lipase) activities. However, estradiol significantly stimulates both prostaglandin cyclooxygenase and prostacyclin synthetase activities of cells, and induction of new protein biosynthesis is involved in the effect of estradiol on the stimulation of prostacyclin biosynthetic activity.

原文英語
頁(從 - 到)472-482
頁數11
期刊Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
620
發行號3
DOIs
出版狀態已發佈 - 十二月 5 1980
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 生物物理學
  • 內分泌
  • 醫藥 (全部)

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