Stimulation of Ethanol Metabolism Induced by Proline and Lysine Ingestion in Prolonged Ethanol-Administered Stroke-Prone Spontaneously Hypertensive Rats

Suh Ching Yang, Michiko Ito, Slamet Budijanto, Yuji Furukawa, Shuichi Kimura, Fumiki Morimatsu

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

The influence of proline and lysine solution ingestion on ethanol metabolism after chronic oral ethanol administration was investigated in stroke-prone spontaneously hypertensive rats (SHRSP). Compared with rats that were not administered ethanol (control group), the prolonged ethanol-administered rats (EtOH group) showed little change in their blood ethanol levels, but a remarkable increase and slow appearance in the blood acetaldehyde levels after the oral administration of ethanol. When prolonged ethanol-administered rats ingested the proline solution (EtOH/Pro group), higher levels of blood ethanol continued. However, the increase in blood acetaldehyde levels was not observed in the EtOH/Pro group. In the case of prolonged ethanol-administered rats that ingested the lysine-containing solution (EtOH/Lys group), blood ethanol levels decreased and disappeared 4 h after the oral administration. An effect of lowered blood acetaldehyde levels was also observed. When prolonged ethanol-administered rats ingested both proline and lysine (EtOH/Pro+Lys group), the effect on blood ethanol levels was similar to that of rats that had ingested lysine only, and the influence on blood acetaldehyde was like that of rats that had only ingested proline. These results suggest that proline and lysine can regulate ethanol metabolism and the influence of proline on ethanol metabolism is different from that of lysine.

原文英語
頁(從 - 到)151-159
頁數9
期刊Journal of Clinical Biochemistry and Nutrition
16
發行號3
DOIs
出版狀態已發佈 - 1994
對外發佈Yes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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