Stimulation of cells derived from nifedipine-induced gingival overgrowth with porphyromonas gingivalis, lipopolysaccharide, and interleukin-1β

H. K. Lu, H. P. Chou, C. L. Li, M. Y. Wang, Leng-Fang Wang

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

The purpose of this study was to clarify the main contributory factor of nifedipine-induced gingival overgrowth either by Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) or interleukin-1 beta (IL-1β). Human gingival fibroblasts from healthy tissues and nifedipine-induced gingival overgrowth tissues were stimulated with nifedipine, IL-1β Escherichia coli lipopolysaccharide (Ec-LPS), and Pg-LPS, and the gene expressions were analyzed by RT-PCR. Analysis of the data showed no strong evidence of a synergistic effect of nifedipine and Pg-LPS on IL-6, connective tissue growth factor (CTGF), and type 1 collagen gene expression of either healthy cells or nifedipine-induced gingival overgrowth cells. Among the three stimulants - IL-1β, Pg-LPS, and Ec-LPS - androgen receptor and IL-6 gene expressions in both the healthy and nifedipine-induced gingival overgrowth groups were strongly up-regulated by the presence of IL-1β only. Furthermore, the responses to IL-1β in the nifedipine-induced gingival overgrowth group were stronger than those of the healthy group. It can be concluded that IL-1β is an important mediator responsible for the higher IL-6 and androgen receptor expression of nifedipine-induced gingival overgrowth cells.
原文英語
頁(從 - 到)1100-1104
頁數5
期刊Journal of Dental Research
86
發行號11
DOIs
出版狀態已發佈 - 十一月 2007

ASJC Scopus subject areas

  • 牙科 (全部)

指紋

深入研究「Stimulation of cells derived from nifedipine-induced gingival overgrowth with porphyromonas gingivalis, lipopolysaccharide, and interleukin-1β」主題。共同形成了獨特的指紋。

引用此