Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol

Wen Chang Chang; Junko Nakao; Hajime Orimo; Hsin Hsiung Tai; Sei Itsu Murota

doi:10.1016/0006-2952(82)90710-9

Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol

Wen Chang Chang, Junko Nakao, Hajime Orimo, Hsin Hsiung Tai, Sei Itsu Murota

研究成果: 雜誌貢獻 › 文章 › 同行評審

15 引文斯高帕斯（Scopus）

摘要

The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.

原文	英語
頁（從 - 到）	2633-2638
頁數	6
期刊	Biochemical Pharmacology
卷	31
發行號	16
DOIs	https://doi.org/10.1016/0006-2952(82)90710-9
出版狀態	已發佈 - 八月 15 1982
對外發佈	Yes

ASJC Scopus subject areas

Pharmacology

存取文件

10.1016/0006-2952(82)90710-9

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引用此

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title = "Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol",

abstract = "The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.",

keywords = "12-HPETE, 12-l-hydoxy-5,8,10,14-eicosatetraenoic acid, 12-l-hydroperoxy-5,8,10,14-eicosatetraenoic acid, 12-l-hydroxy-5,8,10-heptadecatrienoic acid, 2-HETE, and GLC, gas-liquid chromtography, GSH, HHT, reduced glugatione",

author = "Chang, {Wen Chang} and Junko Nakao and Hajime Orimo and Tai, {Hsin Hsiung} and Murota, {Sei Itsu}",

year = "1982",

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T1 - Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol

AU - Chang, Wen Chang

AU - Nakao, Junko

AU - Orimo, Hajime

AU - Tai, Hsin Hsiung

AU - Murota, Sei Itsu

PY - 1982/8/15

Y1 - 1982/8/15

N2 - The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.

AB - The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.

KW - 12-HPETE

KW - 12-l-hydoxy-5,8,10,14-eicosatetraenoic acid

KW - 12-l-hydroperoxy-5,8,10,14-eicosatetraenoic acid

KW - 12-l-hydroxy-5,8,10-heptadecatrienoic acid

KW - 2-HETE

KW - and GLC

KW - gas-liquid chromtography

KW - GSH

KW - HHT

KW - reduced glugatione

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