Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol

Wen Chang Chang, Junko Nakao, Hajime Orimo, Hsin Hsiung Tai, Sei Itsu Murota

研究成果: 雜誌貢獻文章

15 引文 斯高帕斯(Scopus)

摘要

The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.

原文英語
頁(從 - 到)2633-2638
頁數6
期刊Biochemical Pharmacology
31
發行號16
DOIs
出版狀態已發佈 - 八月 15 1982
對外發佈Yes

ASJC Scopus subject areas

  • Pharmacology

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