摘要
The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.
原文 | 英語 |
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頁(從 - 到) | 2633-2638 |
頁數 | 6 |
期刊 | Biochemical Pharmacology |
卷 | 31 |
發行號 | 16 |
DOIs | |
出版狀態 | 已發佈 - 8月 15 1982 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 藥理