Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol

Wen Chang Chang, Junko Nakao, Hajime Orimo, Hsin Hsiung Tai, Sei Itsu Murota

研究成果: 雜誌貢獻文章

15 引文 (Scopus)

摘要

The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.

原文英語
頁(從 - 到)2633-2638
頁數6
期刊Biochemical Pharmacology
31
發行號16
DOIs
出版狀態已發佈 - 八月 15 1982
對外發佈Yes

指紋

Arachidonate 12-Lipoxygenase
Platelets
Rats
Estradiol
Blood Platelets
Phospholipids
Nafoxidine
Fatty Acids
Lipoxygenase
Chemical analysis
Arachidonic Acid
Estrogens

ASJC Scopus subject areas

  • Pharmacology

引用此文

Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol. / Chang, Wen Chang; Nakao, Junko; Orimo, Hajime; Tai, Hsin Hsiung; Murota, Sei Itsu.

於: Biochemical Pharmacology, 卷 31, 編號 16, 15.08.1982, p. 2633-2638.

研究成果: 雜誌貢獻文章

Chang, Wen Chang ; Nakao, Junko ; Orimo, Hajime ; Tai, Hsin Hsiung ; Murota, Sei Itsu. / Stimulation of 12-lipoxygenase activity in rat platelets by 17β-estradiol. 於: Biochemical Pharmacology. 1982 ; 卷 31, 編號 16. 頁 2633-2638.
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abstract = "The effects of estradiol on the endogenous fatty acid (specifically, arachidonic acid) composition of cellular phospholipid fractions and the 12-lipoxygenase activity in rat platelets in vivo were studied. Estradiol had no significant effect on the endogenous fatty acid composition of cellular phospholipid fractions. However, estradiol significantly increased 12-lipoxygenase activity in platelets in a dose-dependent manner. The stimulatory effect of estradiol on platelet lipoxygenase was blocked by the anti-estrogen nafoxidine hydrochloride which was injected simultaneously together with estradiol in vivo, suggesting that the effect in target cells was due directly to estradiol.",
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