Stimulation by prostaglandin F of acidic glycosaminoglycan production in cultured fibroblasts

Wen Chang Chang, Midori Abe, Sei itsu Murota

研究成果: 雜誌貢獻文章同行評審

16 引文 斯高帕斯(Scopus)

摘要

The effect of PGF2α on the synthesis of hexosamine-containing substances (acidic glycosaminoglycans and glycoproteins) was studied in cultured fibroblasts derived from a rat carrageenin granuloma. Treatment with PGF2α ranging from 0.01 μg/ml to 20 μg/ml resulted in a significant increase of the production of these macromolecules by the cells. The stimulatory effect was found significant even at the low concentration of 10 ng/ml, and could be seen as early as 3h after exposure to PGF2α. The hexosamine-containing substances increased by PGF2α revealed that 80% of the increase was due to acidic glycosaminoglycans and the rest was due to glycoproteins.

原文英語
頁(從 - 到)55-63
頁數9
期刊Prostaglandins
13
發行號1
DOIs
出版狀態已發佈 - 1977
對外發佈Yes

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

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