Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71

Luan Yin Chang, Chao A. Hsiung, Chun Yi Lu, Tzou Yien Lin, Fu Yuan Huang, Yu Han Lai, Yu Ping Chiang, Bor Luen Chiang, Chin Yun Lee, Li Min Huang

研究成果: 雜誌貢獻文章

90 引文 斯高帕斯(Scopus)

摘要

We valuated specific cellular and humoral immune response of cases of enterovirus 71 (EV71) infection and correlated immune response with clinical outcome. After obtaining informed consent, we enrolled 30 EV71 cases including 7 cases with brainstem encephalitis plus pulmonary edema, 12 cases of CNS (CNS) involvement and 11 uncomplicated cases. We measured antibodies specific to EV71, lymphocyte proliferation response and EV71-stimulated cellular response of Th1/Th2 cytokines and chemokines. The 7 EV71 cases involving brainstem encephalitis plus pulmonary edema had a significantly lower phytohemagglutinin stimulation index than other cases (p = 0.04). After EV71 stimulation of peripheral mononuclear cells, there was a significant increase in cellular Th1 cytokine (γ-interferon) and proinflammatroy cytokines. However, cases with pulmonary edema had significantly lower cellular γ-interferon (p = 0.04), lower cellular IL-1β (p = 0.04), lower cellular IL-6 (p = 0.04), lower cellular tumor necrosis factor-α response (p = 0.04), and lower cellular macrophage inflammatory protein-1α (p = 0.04) response compared with other cases. Their titers of EV71 neutralizing antibodies demonstrated no difference among cases. These results suggest lower EV71-specific cellular response may be associated with immunopathogenesis of EV71-related pulmonary edema.
原文英語
頁(從 - 到)466-471
頁數6
期刊Pediatric Research
60
發行號4
DOIs
出版狀態已發佈 - 十月 2006
對外發佈Yes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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    Chang, L. Y., Hsiung, C. A., Lu, C. Y., Lin, T. Y., Huang, F. Y., Lai, Y. H., Chiang, Y. P., Chiang, B. L., Lee, C. Y., & Huang, L. M. (2006). Status of cellular rather than humoral immunity is correlated with clinical outcome of enterovirus 71. Pediatric Research, 60(4), 466-471. https://doi.org/10.1203/01.pdr.0000238247.86041.19