@article{2324d5d6f5cf4ca0a784e24549408f49,
title = "Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan",
abstract = "Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000-01 through 2011-12. Using data from Taiwan's National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use.",
keywords = "critical illness, hospitalization, influenza, respiratory diseases, Taiwan, vaccine-preventable diseases, vaccines, viruses",
author = "Tsai, {Lung Wen} and Chen, {Yung Tai} and Shih, {Chia Jen} and Ou, {Shuo Ming} and Chao, {Pei Wen} and Lo, {Shih Hsiu}",
note = "Funding Information: This work was supported in part by the Novel Bioengineering and Technological Approaches to Solve Two Major Health Problems in Taiwan sponsored by the Taiwan Ministry of Science and Technology (MOST) Academic Excellence Program (MOST grant nos. 105-2633-B-009-003, 107-2314-B-075-052, and 108-2314-B-075-008); Wan Fang Hospital (grant nos. 105swf0 and, 106-swf-06); Taipei City Government (grant nos. 10701-62-054 and10801-62-051); Taipei Veterans General Hospital (grant nos. V105A-003, V106B-009, V107B-027, V108B-023, V109B-022, and V109D50-001-MY3-1); Taipei Veterans General Hospital-National Yang-Ming University Excellent Physician Scientists Cultivation Program (grant no. 104-V-B-044); Taipei Medical University Hospital (grant no. 105TMUH-SP-07).",
year = "2020",
month = jun,
day = "1",
doi = "10.3201/eid2606.190646",
language = "English",
volume = "26",
pages = "1243--1250",
journal = "Emerging Infectious Diseases",
issn = "1080-6040",
publisher = "Centers for Disease Control and Prevention (CDC)",
number = "6",
}