Stability of curcumin in buffer solutions and characterization of its degradation products

Ying J. Wang, Min Hsiung Pan, Ann L. Cheng, Liang I. Lin, Yuan Soon Ho, Chang Y. Hsieh, Jen K. Lin

研究成果: 雜誌貢獻文章同行評審

1227 引文 斯高帕斯(Scopus)

摘要

The degradation kinetics of curcumin under various pH conditions and the stability of curcumin in physiological matrices were investigated. When curcumin was incubated in 0.1 M phosphate buffer and serum-free medium, pH 7.2 at 37°C, about 90% decomposed within 30 min. A series of pH conditions ranging from 3 to 10 were tested and the result showed that decomposition was pH-dependent and occurred faster at neutral-basic conditions. It is more stable in cell culture medium containing 10% fetal calf serum and in human blood; less than 20% of curcumin decomposed within 1 h, and after incubation for 8 h, about 50% of curcumin is still remained. Trans-6-(4'-hydroxy-3'-methoxyphenyl)-2,4-dioxo-5-hexenal was predicted as major degradation product and vanillin, ferulic acid, feruloyl methane were identified as minor degradation products. The amount of vanillin increased with incubation time.

原文英語
頁(從 - 到)1867-1876
頁數10
期刊Journal of Pharmaceutical and Biomedical Analysis
15
發行號12
DOIs
出版狀態已發佈 - 八月 1997
對外發佈

ASJC Scopus subject areas

  • 分析化學
  • 藥學科學

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