Sponge-Derived 24-Homoscalaranes as Potent Anti-Inflammatory Agents

Bo Rong Peng, Kuei Hung Lai, Yu Chia Chang, You Ying Chen, Jui Hsin Su, Yusheng M. Huang, Po Jen Chen, Steve Sheng Fa Yu, Chang Yih Duh, Ping Jyun Sung

研究成果: 雜誌貢獻文章同行評審

摘要

Scalarane-type sesterterpenoids are known for their therapeutic potential in cancer treatments. However, the anti-inflammatory properties of this class of metabolites remain elusive. Our current work aimed to investigate the anti-inflammatory scalaranes from marine sponge Lendenfeldia sp., resulting in the isolation of six new 24-homoscalaranes, lendenfeldaranes E-J (1-6). The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by electronic circular dichroism (ECD) calculations. Compounds 2 and 3 were discovered to individually reduce the generation of superoxide anions, and compound 1 displayed an inhibitor effect on the release of elastase. These three compounds were proven to be the first anti-neutrophilic scalaranes.

原文英語
期刊Marine Drugs
18
發行號9
DOIs
出版狀態已發佈 - 八月 19 2020

ASJC Scopus subject areas

  • Drug Discovery

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