A method for obtaining localized spectra from arbitrarily shaped regions of interest is described. When a sample consists of homogeneous compartments or domains, spectra localized in each compartment can be obtained from signals of single voxels with regular shapes by solving a set of simultaneous linear equations. Experimental demonstrations on a phantom and on human brain in vivo for a two compartment, two voxel case are presented. The issue of signal-to-noise ratio is also discussed.
ASJC Scopus subject areas
- Clinical Biochemistry
- Structural Biology
- Radiology Nuclear Medicine and imaging
- Condensed Matter Physics
Wang, Z., Reddy, R., Haselgrove, J. C., Chen, C. Y., Goelman, G., Zimmerman, R. A., & Leigh, J. S. (1993). Spectral localization of arbitrarily shaped regions of interest (SLASH) using single voxel signals. Magnetic Resonance Imaging, 11(8), 1203-1208. https://doi.org/10.1016/0730-725X(93)90248-C