Spectral analysis of arterial blood pressure and cerebral blood flow velocity during supine rest and orthostasis

Chang Ming Chern, Terry Bo Jau Kuo, Wen Yung Sheng, Wen Jang Wong, Yung On Luk, Li Chi Hsu, Han Hwa Hu

研究成果: 雜誌貢獻文章

17 引文 斯高帕斯(Scopus)

摘要

This study evaluates the effect of orthostasis on the low frequency (LF, 0.04 to 0.15 Hz) fluctuations in the blood flow velocity of the middle cerebral artery (MCAFV) in relation to its arterial blood pressure (ABP) equivalent to further define and quantify this relationship in cerebrovascular regulation. Spectral analysis was performed on 22 healthy subjects during supine rest and head-up tilt. The power in the LF range can be used to quantify the LF fluctuations, and four types of LF power data could be obtained for each individual: LF power of supine MCAFV, LF power of supine ABP, LF power of tilt MCAFV, and LF power of tilt ABP. By comparing LF power of MCAFV with LF power of ABP, two power ratios could be generated to describe the flow-pressure relationship during supine rest and head-up tilt, respectively, supine power ratio (LF power of supine MCAFV/LF power of supine ABP) and tilt power ratio (LF power of flit MCAFV/LF power of tilt ABP). In addition, an index for dynamic autoregulation in response to orthostasis can be calculated from these two power ratios frill power ratio/supine power ratio). The authors found that this index was dependent on the extent of orthostatic MCAFV changes, and the dependency could be mathematically expressed (r = 0.61, P = .0001), suggesting its involvement in cerebrovascular regulation. Moreover, these data further support the previous observation that the LF fluctuations of MCAFV might result from modulation of its ABP equivalent, and the modulation effect could be quantified as the power ratio (LF power of MCAFV/LF power of ABP). These observations could be an important step toward further insight into cerebrovascular regulation, which warrants more research in the future.
原文英語
頁(從 - 到)1136-1141
頁數6
期刊Journal of Cerebral Blood Flow and Metabolism
19
發行號10
出版狀態已發佈 - 1999
對外發佈Yes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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