Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)

J. Whang-Peng, C. S. Kao-Shan, E. C. Lee, P. A. Bunn, D. N. Carney, A. F. Gazdar, J. D. Minna

研究成果: 雜誌貢獻 › 文章

391 引文 (Scopus)

摘要

A specific, acquired chromosomal abnormality (deletion 3p) has been found in at least one chromosome 3 in 100 percent of the metaphases in 12 of 12 cell lines cultured from human small-cell lung cancer tissue and in 2-day tumor culture specimens from three patients. Analysis of the shortest region of overlap shows the deletion to be 3p(14-23). This specific change was not seen in five of five lung cancer cell lines other than small-cell lung cancer or in two lymphoblastoid lines cultured from cells of small-cell lung cancer patients whose tumors had the 3p deletion.
原文英語
頁（從 - 到）181-182
頁數2
期刊Science
卷215
發行號4529
出版狀態已發佈 - 一月 1 1982
對外發佈Yes

指紋

Small Cell Lung Carcinoma
Chromosomes
Cell Line
Chromosomes, Human, Pair 3
Metaphase
Chromosome Aberrations
Cultured Cells
Lung Neoplasms
Neoplasms
Monosomy 3p Chromosome 3

ASJC Scopus subject areas

  • Medicine(all)
  • General

引用此文

Whang-Peng, J., Kao-Shan, C. S., Lee, E. C., Bunn, P. A., Carney, D. N., Gazdar, A. F., & Minna, J. D. (1982). Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23). Science, 215(4529), 181-182.

Specific chromosome defect associated with human small-cell lung cancer : Deletion 3p(14-23). / Whang-Peng, J.; Kao-Shan, C. S.; Lee, E. C.; Bunn, P. A.; Carney, D. N.; Gazdar, A. F.; Minna, J. D.

於: Science, 卷 215, 編號 4529, 01.01.1982, p. 181-182.

研究成果: 雜誌貢獻 › 文章

Whang-Peng, J, Kao-Shan, CS, Lee, EC, Bunn, PA, Carney, DN, Gazdar, AF & Minna, JD 1982, 'Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23)', Science, 卷 215, 編號 4529, 頁 181-182.
Whang-Peng J, Kao-Shan CS, Lee EC, Bunn PA, Carney DN, Gazdar AF 等. Specific chromosome defect associated with human small-cell lung cancer: Deletion 3p(14-23). Science. 1982 1月 1;215(4529):181-182.
Whang-Peng, J. ; Kao-Shan, C. S. ; Lee, E. C. ; Bunn, P. A. ; Carney, D. N. ; Gazdar, A. F. ; Minna, J. D. / Specific chromosome defect associated with human small-cell lung cancer : Deletion 3p(14-23). 於: Science. 1982 ; 卷 215, 編號 4529. 頁 181-182.
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