Soy Saponins Meditate the Progression of Colon Cancer in Rats by Inhibiting the Activity of β -Glucuronidase and the Number of Aberrant Crypt Foci but Not Cyclooxygenase-2 Activity

Yu-Wei Guo, Yue-Hwa Chen, Wan-Chun Chiu, Hsiang Liao, Shyh-Hsiang Lin

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摘要

Objective. The effect of extracted crude soybean saponins on preneoplastic lesions, aberrant crypt foci (ACF), and the related mechanism were investigated. Research Methods and Procedures. Rats were assigned into five groups according to different doses of extracted crude soybean saponins and received 1,2-dimethylhydrazine (DMH) injection in week 5. In week 15, all rats were sacrificed. The number of ACFs, the cyclooxygenase-2 (COX-2) protein expression, the level of prostaglandins E2 (PGE2), and the activity of β -glucuronidase were examined. Results. Results revealed that the consumption of extracted crude soybean saponins decreased the number of ACFs and the activity of β -glucuronidase in rats, while the expression of COX-2 protein and PGE2 level were not affected. Conclusions. Soybean saponins were effective in inhibiting colon cancer by downregulating the activity of β -glucuronidase in colonic mucosa but not the COX-2 protein expression and PGE2 level.
原文英語
頁(從 - 到)645817
期刊ISRN oncology
2013
DOIs
出版狀態已發佈 - 2013

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