Sorting nexin 24 genetic variation associates with coronary artery aneurysm severity in Kawasaki disease patients

Ying Ju Lin, Jeng Sheng Chang, Xiang Liu, Ting Hsu Lin, Shao Mei Huang, Chiu Chu Liao, Cheng Wen Lin, Wen Kuei Chien, Jin Hua Chen, Jer Yuarn Wu, Chien Hsiun Chen, Li Ching Chang, Hsinyi Tsang, Kuan Teh Jeang, Chia Yen Chen, Fuu Jen Tsai

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9 引文 斯高帕斯(Scopus)

摘要

Background: The sorting nexin (SNX) family is involved in endocytosis and protein trafficking and plays multiple roles in various diseases. The role of SNX proteins in Kawasaki disease (KD) is not known. We attempted to test whether genetic SNX variation associates with the risk of coronary artery aneurysm (CAA) formation in KD.Methods and results: Chi-square tests were used to identify SNX24 genetic variants associated with KD susceptibility and CAA formation in KD; models were adjusted for fever duration and time of first administration of intravenous immunoglobulin. We obtained clinical characteristics and genotypes from KD patients (76 with CAA and 186 without CAA) in a population-based retrospective KD cohort study (n = 262). Clinical and genetic factors were associated with CAA formation in KD. In addition, endothelial cell inflammation was evaluated. Significant correlation was observed between KD with CAA complications and the rs28891 single-nucleotide polymorphism in SNX24. Patients with CC + CT genotypes had lesser CAA complications. In lipopolysaccharide-treated human umbilical vein endothelial cells, siRNA knockdown of SNX24 significantly decreased gene expression of the proinflammatory cytokines IL-1 beta, IL-6, and IL-8.Conclusions: Polymorphisms in SNX24 may be used as genetic markers for the diagnosis and prognosis of CAA formation in KD.

原文英語
文章編號44
期刊Cell and Bioscience
3
發行號1
DOIs
出版狀態已發佈 - 十一月 22 2013

ASJC Scopus subject areas

  • 生物化學、遺傳與分子生物學 (全部)

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