Sonographic patterns of the endometrium in assessment of medical abortion outcomes

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Background: We aimed to define endometrial pattern and endometrial thickness in predicting the outcome of early medical abortion. Study Design: While blinded to outcomes of abortion, we retrospectively reviewed the ultrasound scan performed 14-21 days after medical abortion. We assessed the endometrial pattern and endometrial thickness. A total of 943 women at or before 56 days of gestation who underwent medical abortions were included. Abortion was induced with mifepristone (600 mg) orally followed 48 h later with oral misoprostol (600 mcg). A successful medical abortion was defined as complete abortion without surgical intervention. Three sonographic patterns (homogenous, heterogeneous and multilayered) were devised to correlate with the outcome. Results: Of the 940 women, 92 (9.8%) had failed medical abortions. Eighty-seven (94.6%) patients with failed treatment outcomes had a heterogeneous pattern, while no patients with failed treatments had a multilayered pattern. Based on multivariable logistic regression, women who had an endometrial thickness in the range of 10-15 or > 15 mm were more likely to have failed outcomes than those with a thickness <10 mm, with ORs of 3.69 (p=.001) and 8.82 (p 10 mm in combination with a heterogeneous pattern had the highest balanced accuracy in the prediction of failed outcome (81.9%; 95% CI, 77.6-86.3). Conclusion: Women with a multilayered pattern could be reassured that they have successful medical abortion, while those with a heterogeneous pattern and/or endometrium > 10 mm may need follow-up. Sonographic endometrial pattern and endometrial thickness may serve as objective criteria in the management of early medical abortions.
原文英語
頁(從 - 到)153-159
頁數7
期刊Contraception
88
發行號1
DOIs
出版狀態已發佈 - 七月 2013

指紋

Endometrium
Misoprostol
Mifepristone
Induced Abortion
Logistic Models
Pregnancy
Therapeutics

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

引用此文

Sonographic patterns of the endometrium in assessment of medical abortion outcomes. / Tzeng, Chii Ruey; Hwang, Jiann-Loung; Au, Heng Kien; Chien, Li Wei.

於: Contraception, 卷 88, 編號 1, 07.2013, p. 153-159.

研究成果: 雜誌貢獻文章

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abstract = "Background: We aimed to define endometrial pattern and endometrial thickness in predicting the outcome of early medical abortion. Study Design: While blinded to outcomes of abortion, we retrospectively reviewed the ultrasound scan performed 14-21 days after medical abortion. We assessed the endometrial pattern and endometrial thickness. A total of 943 women at or before 56 days of gestation who underwent medical abortions were included. Abortion was induced with mifepristone (600 mg) orally followed 48 h later with oral misoprostol (600 mcg). A successful medical abortion was defined as complete abortion without surgical intervention. Three sonographic patterns (homogenous, heterogeneous and multilayered) were devised to correlate with the outcome. Results: Of the 940 women, 92 (9.8{\%}) had failed medical abortions. Eighty-seven (94.6{\%}) patients with failed treatment outcomes had a heterogeneous pattern, while no patients with failed treatments had a multilayered pattern. Based on multivariable logistic regression, women who had an endometrial thickness in the range of 10-15 or > 15 mm were more likely to have failed outcomes than those with a thickness <10 mm, with ORs of 3.69 (p=.001) and 8.82 (p 10 mm in combination with a heterogeneous pattern had the highest balanced accuracy in the prediction of failed outcome (81.9{\%}; 95{\%} CI, 77.6-86.3). Conclusion: Women with a multilayered pattern could be reassured that they have successful medical abortion, while those with a heterogeneous pattern and/or endometrium > 10 mm may need follow-up. Sonographic endometrial pattern and endometrial thickness may serve as objective criteria in the management of early medical abortions.",
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AB - Background: We aimed to define endometrial pattern and endometrial thickness in predicting the outcome of early medical abortion. Study Design: While blinded to outcomes of abortion, we retrospectively reviewed the ultrasound scan performed 14-21 days after medical abortion. We assessed the endometrial pattern and endometrial thickness. A total of 943 women at or before 56 days of gestation who underwent medical abortions were included. Abortion was induced with mifepristone (600 mg) orally followed 48 h later with oral misoprostol (600 mcg). A successful medical abortion was defined as complete abortion without surgical intervention. Three sonographic patterns (homogenous, heterogeneous and multilayered) were devised to correlate with the outcome. Results: Of the 940 women, 92 (9.8%) had failed medical abortions. Eighty-seven (94.6%) patients with failed treatment outcomes had a heterogeneous pattern, while no patients with failed treatments had a multilayered pattern. Based on multivariable logistic regression, women who had an endometrial thickness in the range of 10-15 or > 15 mm were more likely to have failed outcomes than those with a thickness <10 mm, with ORs of 3.69 (p=.001) and 8.82 (p 10 mm in combination with a heterogeneous pattern had the highest balanced accuracy in the prediction of failed outcome (81.9%; 95% CI, 77.6-86.3). Conclusion: Women with a multilayered pattern could be reassured that they have successful medical abortion, while those with a heterogeneous pattern and/or endometrium > 10 mm may need follow-up. Sonographic endometrial pattern and endometrial thickness may serve as objective criteria in the management of early medical abortions.

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