Somatic neuropathy is an independent predictor of all- and diabetes-related mortality in type 2 diabetic patients: A population-based 5-year follow-up study (KCIS No. 29)

W. C. Hsu, S. Y H Chiu, A. M F Yen, L. S. Chen, C. Y. Fann, C. S. Liao, H. H. Chen

研究成果: 雜誌貢獻文章

16 引文 (Scopus)

摘要

Background and purpose: To investigate the relationships of diabetic neuropathy to all-cause and diabetes-related mortality in patients with type 2 diabetes after controlling for significant correlates. Methods: We examined 326 patients diagnosed as diabetic polyneuropathy by nerve conduction study in Keelung city, Taiwan, in 2002 and followed them up to ascertain the cause and date of death until the end of 2006. The cause and date of death were recorded for the deceased patients. Information on significant correlates in association with diabetic polyneuropathy and all-cause and diabetes-related mortality was also collected. Results: With median follow-up time of 62.28months, 44 patients with type 2 diabetes died. The cause of death related to diabetes accounted for 59% (n=26) of the deceased. Univariate analysis shows that the presence of diabetic neuropathy confers higher risk for all-cause mortality (hazard ratio [HR]=4.88) and mortality from diabetes (HR=6.58). The significant finding still persisted after adjustment for age, gender, blood pressure, smoking, history of cardiovascular/cerebrovascular disease, duration of diabetes, waist circumference, fasting plasma glucose, total cholesterol, hemoglobin, and creatinine (adjusted HR=4.44 for all-cause death and adjusted HR=11.82 for diabetes-related mortality, respectively). Conclusions: Diabetic polyneuropathy was an independent predictor for all-cause and diabetes-related mortality. The presence of neuropathy together with other significant prognostic factors is informative to predict all-cause death and death from diabetes-related disease for patients diagnosed as type 2 diabetes.
原文英語
頁(從 - 到)1192-1198
頁數7
期刊European Journal of Neurology
19
發行號9
DOIs
出版狀態已發佈 - 九月 2012

指紋

Diabetic Neuropathies
Cause of Death
Mortality
Type 2 Diabetes Mellitus
Population
Cerebrovascular Disorders
Neural Conduction
Waist Circumference
Taiwan
Fasting
Creatinine
Hemoglobins
Cardiovascular Diseases
Smoking
Cholesterol
Blood Pressure
Glucose

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

引用此文

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title = "Somatic neuropathy is an independent predictor of all- and diabetes-related mortality in type 2 diabetic patients: A population-based 5-year follow-up study (KCIS No. 29)",
abstract = "Background and purpose: To investigate the relationships of diabetic neuropathy to all-cause and diabetes-related mortality in patients with type 2 diabetes after controlling for significant correlates. Methods: We examined 326 patients diagnosed as diabetic polyneuropathy by nerve conduction study in Keelung city, Taiwan, in 2002 and followed them up to ascertain the cause and date of death until the end of 2006. The cause and date of death were recorded for the deceased patients. Information on significant correlates in association with diabetic polyneuropathy and all-cause and diabetes-related mortality was also collected. Results: With median follow-up time of 62.28months, 44 patients with type 2 diabetes died. The cause of death related to diabetes accounted for 59{\%} (n=26) of the deceased. Univariate analysis shows that the presence of diabetic neuropathy confers higher risk for all-cause mortality (hazard ratio [HR]=4.88) and mortality from diabetes (HR=6.58). The significant finding still persisted after adjustment for age, gender, blood pressure, smoking, history of cardiovascular/cerebrovascular disease, duration of diabetes, waist circumference, fasting plasma glucose, total cholesterol, hemoglobin, and creatinine (adjusted HR=4.44 for all-cause death and adjusted HR=11.82 for diabetes-related mortality, respectively). Conclusions: Diabetic polyneuropathy was an independent predictor for all-cause and diabetes-related mortality. The presence of neuropathy together with other significant prognostic factors is informative to predict all-cause death and death from diabetes-related disease for patients diagnosed as type 2 diabetes.",
keywords = "Diabetic polyneuropathy, Mortality, Population-based study, Predictor, Type 2 diabetes",
author = "Hsu, {W. C.} and Chiu, {S. Y H} and Yen, {A. M F} and Chen, {L. S.} and Fann, {C. Y.} and Liao, {C. S.} and Chen, {H. H.}",
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TY - JOUR

T1 - Somatic neuropathy is an independent predictor of all- and diabetes-related mortality in type 2 diabetic patients

T2 - A population-based 5-year follow-up study (KCIS No. 29)

AU - Hsu, W. C.

AU - Chiu, S. Y H

AU - Yen, A. M F

AU - Chen, L. S.

AU - Fann, C. Y.

AU - Liao, C. S.

AU - Chen, H. H.

PY - 2012/9

Y1 - 2012/9

N2 - Background and purpose: To investigate the relationships of diabetic neuropathy to all-cause and diabetes-related mortality in patients with type 2 diabetes after controlling for significant correlates. Methods: We examined 326 patients diagnosed as diabetic polyneuropathy by nerve conduction study in Keelung city, Taiwan, in 2002 and followed them up to ascertain the cause and date of death until the end of 2006. The cause and date of death were recorded for the deceased patients. Information on significant correlates in association with diabetic polyneuropathy and all-cause and diabetes-related mortality was also collected. Results: With median follow-up time of 62.28months, 44 patients with type 2 diabetes died. The cause of death related to diabetes accounted for 59% (n=26) of the deceased. Univariate analysis shows that the presence of diabetic neuropathy confers higher risk for all-cause mortality (hazard ratio [HR]=4.88) and mortality from diabetes (HR=6.58). The significant finding still persisted after adjustment for age, gender, blood pressure, smoking, history of cardiovascular/cerebrovascular disease, duration of diabetes, waist circumference, fasting plasma glucose, total cholesterol, hemoglobin, and creatinine (adjusted HR=4.44 for all-cause death and adjusted HR=11.82 for diabetes-related mortality, respectively). Conclusions: Diabetic polyneuropathy was an independent predictor for all-cause and diabetes-related mortality. The presence of neuropathy together with other significant prognostic factors is informative to predict all-cause death and death from diabetes-related disease for patients diagnosed as type 2 diabetes.

AB - Background and purpose: To investigate the relationships of diabetic neuropathy to all-cause and diabetes-related mortality in patients with type 2 diabetes after controlling for significant correlates. Methods: We examined 326 patients diagnosed as diabetic polyneuropathy by nerve conduction study in Keelung city, Taiwan, in 2002 and followed them up to ascertain the cause and date of death until the end of 2006. The cause and date of death were recorded for the deceased patients. Information on significant correlates in association with diabetic polyneuropathy and all-cause and diabetes-related mortality was also collected. Results: With median follow-up time of 62.28months, 44 patients with type 2 diabetes died. The cause of death related to diabetes accounted for 59% (n=26) of the deceased. Univariate analysis shows that the presence of diabetic neuropathy confers higher risk for all-cause mortality (hazard ratio [HR]=4.88) and mortality from diabetes (HR=6.58). The significant finding still persisted after adjustment for age, gender, blood pressure, smoking, history of cardiovascular/cerebrovascular disease, duration of diabetes, waist circumference, fasting plasma glucose, total cholesterol, hemoglobin, and creatinine (adjusted HR=4.44 for all-cause death and adjusted HR=11.82 for diabetes-related mortality, respectively). Conclusions: Diabetic polyneuropathy was an independent predictor for all-cause and diabetes-related mortality. The presence of neuropathy together with other significant prognostic factors is informative to predict all-cause death and death from diabetes-related disease for patients diagnosed as type 2 diabetes.

KW - Diabetic polyneuropathy

KW - Mortality

KW - Population-based study

KW - Predictor

KW - Type 2 diabetes

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